Medical device with coating that promotes endothelial cell adherence
First Claim
1. A method for delivering a stent into a patient, the method comprising the step of:
- implanting a stent with a coating to a patient in need of said stent;
wherein said coating comprises one or more layers of a matrix attached to said stent;
said one or more layers of the matrix containing one or more pharmaceutical substances, wherein the pharmaceutical substance inhibits smooth muscle cell proliferation and/or migration; and
wherein the coating further comprises a therapeutically effective amount of an antibody, antibody fragments or combinations thereof, and wherein said antibody, antibody fragments or combinations thereof specifically binds to a cell surface antigen of endothelial progenitor cells or endothelial cells in peripheral blood.
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Accused Products
Abstract
The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ.
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Citations
20 Claims
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1. A method for delivering a stent into a patient, the method comprising the step of:
implanting a stent with a coating to a patient in need of said stent;
wherein said coating comprises one or more layers of a matrix attached to said stent;said one or more layers of the matrix containing one or more pharmaceutical substances, wherein the pharmaceutical substance inhibits smooth muscle cell proliferation and/or migration; and wherein the coating further comprises a therapeutically effective amount of an antibody, antibody fragments or combinations thereof, and wherein said antibody, antibody fragments or combinations thereof specifically binds to a cell surface antigen of endothelial progenitor cells or endothelial cells in peripheral blood. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
Specification