TLR4 inhibitors for the treatment of human infectious and inflammatory disorders
First Claim
1. A method of treating an infectious or inflammatory disorder comprising administering, to a subject in need of such treatment, an effective amount of a Toll-like receptor 4 inhibitor compound selected from the compounds listed in TABLE 1 that reduces one or more sign or symptom of inflammation in the subject.
0 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to methods of treating infectious, inflammatory and post-traumatic disorders by administering various compounds newly discovered to have TLR4 inhibitory activity. In addition to methods of treatment, the present invention further provides for pharmaceutical compositions comprising said compounds, together with a suitable pharmaceutical carrier. Because TLR4 is the most upstream receptor in the pro-inflammatory LPS signaling cascade, treatments of the invention, which inhibit or antagonize TLR4 action, may avoid the pitfalls associated with other cytokine inhibitors that act further down the pathway and accordingly play a less specific (and perhaps non-critical) role.
32 Citations
26 Claims
- 1. A method of treating an infectious or inflammatory disorder comprising administering, to a subject in need of such treatment, an effective amount of a Toll-like receptor 4 inhibitor compound selected from the compounds listed in TABLE 1 that reduces one or more sign or symptom of inflammation in the subject.
- 6. A method of treating an intestinal inflammatory disorder in a subject comprising administering, to a subject in need of such treatment, an effective amount of a T4IC selected from the compounds listed in TABLE 1 that reduces intestinal inflammation in the subject.
- 12. A method of treating a cardiovascular disease in a subject comprising administering, to a subject in need of such treatment, an effective amount of a Toll-like receptor 4 inhibitor compound selected from the compounds listed in TABLE 1 that reduces myocardial ischemia in the subject.
- 18. A method of treating a traumatic injury in a subject comprising administering, to a subject in need of such treatment, an effective amount of a Toll-like receptor 4 inhibitor compound selected from the compounds listed in TABLE 1 that reduces Toll-like receptor 4-induced post-traumatic injury.
-
26. A pharmaceutical composition comprising a therapeutically effective amount of a of isopropyl 3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxyhexopyranoside derivative selected from the group consisting of:
Specification
-
- Resources
-
Current AssigneeUniversity of Pittsburgh of The Commonwealth System of Higher Education
-
Original AssigneeUniversity of Pittsburgh of The Commonwealth System of Higher Education
-
InventorsWipf, Peter, Neal, Matthew D., Chhinder, Sodhi P., Hackam, David J.
-
Primary Examiner(s)LEWIS, PATRICK T
-
Application NumberUS13/848,809Publication NumberTime in Patent Office837 DaysField of SearchNoneUS Class Current1/1CPC Class CodesA61K 31/351 not condensed with another ...A61K 31/7008 Compounds having an amino g...A61K 31/7024 Esters of saccharidesA61K 31/7028 Compounds having saccharide...A61K 31/7034 attached to a carbocyclic c...
