Compositions and methods for surface abrasion with frozen particles

• US 9,072,799 B2
• Filed: 10/31/2008
• Issued: 07/07/2015
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Cook, Daniel B., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): RIDER, LANCE W
• Application Number:
  US12/290,664
• Publication Number:
  US 20100111830A1
• Time in Patent Office: 2,440 Days
• US Class Current: 1/1
• CPC Class Codes: A61K 51/1244 microparticles or nanoparticles, e.g. polymeric nanoparticles
• CPC Class Codes: A61K 9/00 Medicinal preparations characterised by special physical form nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations A61K49/18; preparations containing radioactive substances A61K51/12
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/1611 Inorganic compounds

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A composition, comprising:

one or more frozen particles containing at least one antibiotic, at least one anti-tumor agent, at least one cytokine, and one or more reinforcement agents of metal or cellulose; and

wherein the one or more frozen particles have at least one major dimension of approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

2. The composition of claim 1, further including one or more abrasives.

3. The composition of claim 1, wherein the one or more frozen particles include at least one of amorphous solid water, low density amorphous ice, high density amorphous ice, crystalline ice, very high density amorphous ice, clathrate ice, or hyperquenched glassy water.

4. The composition of claim 1, wherein the one or more frozen particles include at least one of ice Ic, ice Ih, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, or ice XIV.

5. The composition of claim 1, wherein the one or more frozen particles further include at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether.

6. The composition of claim 1, further including at least one of a polymer, biopolymer, nanoparticle, or detection material.

7. The composition of claim 6, wherein the detection material includes at least one electronic identification device.

8. The composition of claim 7, wherein the at least one electronic identification device includes at least one radio frequency identification device.

9. The composition of claim 6, wherein the detection material includes at least one radioactive element.

10. The composition of claim 9, wherein the at least one radioactive element includes one or more of ³²P, ³⁵S, ¹³C, ¹³¹I, ¹⁹¹Ir, ¹⁹²Ir, ¹⁹³Ir, ²⁰¹Tl, or ³H.

11. The composition of claim 6, wherein the detection material includes at least one colorimetric substance.

12. The composition of claim 11, wherein the at least one colorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.

13. The composition of claim 11, wherein the at least one colorimetric substance includes one or more of a dye, pigment, or light-emitting substance.

14. The composition of claim 13, wherein the light-emitting substance includes at least one of a fluorescent substance, phosphorescent substance, or quantum dot.

15. The composition of claim 6, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

16. The composition of claim 1, wherein the one or more frozen particles include a plurality of frozen particles that are approximately uniform with regard to size, shape, weight, or density.

17. The composition of claim 1, further including at least one pharmaceutically-acceptable carrier or excipient.

18. The composition of claim 1, further including one or more explosive materials.

19. The composition of claim 18, wherein the one or more explosive materials include at least one of a high explosive or a low explosive.

20. The composition of claim 18, wherein the one or more explosive materials include at least one of carbon dioxide, nitroglycerine, or a reactive metal.

21. A composition, comprising:

one or more frozen dimethylsulfoxide solution particles containing one or more antibodies and one or more explosive materials, wherein the one or more explosive materials do not include carbon dioxide;

wherein the composition is in at least one crystalline or amorphous phase.

22. The composition of claim 21, wherein the one or more frozen particles have at least one major dimension of approximately one micrometer or less, approximately one nanometer or less, or any value therebetween.

23. The composition of claim 21, further including one or more of fiberglass, silica beads, wood fibers, or kaolin.

24. The composition of claim 21, further including one or more of vectran, or silicon.

25. The composition of claim 21, wherein the one or more frozen particles include at least one of amorphous solid water, low density amorphous ice, high density amorphous ice, crystalline ice, very high density amorphous ice, clathrate ice, or hyperquenched glassy water.

26. The composition of claim 21, wherein the one or more frozen particles include at least one of ice Ic, ice Ih, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, or ice XIV.

27. The composition of claim 21, wherein the one or more frozen particles further include at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer'"'"'s solution, lactated Ringer'"'"'s solution, Hartmann'"'"'s solution, acetated Ringer'"'"'s solution, phosphate buffered solution, TRIS-buffered saline solution, Hank'"'"'s balanced salt solution, Earle'"'"'s balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether.

28. The composition of claim 21, further including at least one of an anesthetic, analgesic, or antimicrobial agent.

29. The composition of claim 21, further including at least one of a polymer, biopolymer, nanoparticle, or detection material.

30. The composition of claim 29, wherein the detection material includes at least one electronic identification device.

31. The composition of claim 30, wherein the at least one electronic identification device includes at least one radio frequency identification device.

32. The composition of claim 29, wherein the detection material includes at least one radioactive element.

33. The composition of claim 32, wherein the at least one radioactive element includes one or more of ³²P, ³⁵S, ¹³C, ¹³¹I, ¹⁹¹Ir, ¹⁹²Ir, ¹⁹³Ir, ²⁰¹Tl, or ³H.

34. The composition of claim 29, wherein the detection material includes at least one colorimetric substance.

35. The composition of claim 34, wherein the at least one colorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance.

36. The composition of claim 34, wherein the at least one colorimetric substance includes one or more of a dye, pigment, or light-emitting substance.

37. The composition of claim 36, wherein the light-emitting substance includes at least one of a fluorescent substance, phosphorescent substance, or quantum dot.

38. The composition of claim 29, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle.

39. The composition of claim 21, wherein the one or more frozen particles include a plurality of frozen hydrogen oxide particles that are approximately uniform with regard to size, shape, weight, or density.

40. The composition of claim 21, formulated to be administered by high velocity impact.

41. The composition of claim 21, formulated to be administered by one or more devices.

42. The composition of claim 21, further including at least one pharmaceutically-acceptable carrier or excipient.

43. The composition of claim 21, wherein the one or more explosive materials include at least one of a high explosive or a low explosive.

44. The composition of claim 21, wherein the one or more explosive materials include at least one of carbon dioxide, nitroglycerine, or a reactive metal.