Mineralization and biological modification of biomaterial surfaces
First Claim
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1. A method for controlling mineralization of a biomaterial surface, comprisingfunctionalizing at least a first surface of a biomaterial by at least one of:
- chemical hydrolysis, electrolysis, or electromagnetic radiation; and
contacting the functionalized biomaterial surface with an amount of a mineral-containing solution effective to form a mineralized biomaterial that comprises an extended, mineral coating at the functionalized biomaterial surface;
said biomaterial comprising at least a first porous, biodegradable polymer portion that has an interconnected pore structure and that is degradable over a controllable time scale,wherein the polymer portion of the biomaterial is a poly(alpha-hydroxy acid),wherein the poly(alpha-hydroxy acid) is a polylactic acid polymer, a polyglycolic acid polymer or a polylactic-co-glycolic acid copolymer, andwherein the functionalization provides for specific control over the mineral coating on the biomaterial surface.
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Abstract
Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
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Citations
19 Claims
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1. A method for controlling mineralization of a biomaterial surface, comprising
functionalizing at least a first surface of a biomaterial by at least one of: - chemical hydrolysis, electrolysis, or electromagnetic radiation; and
contacting the functionalized biomaterial surface with an amount of a mineral-containing solution effective to form a mineralized biomaterial that comprises an extended, mineral coating at the functionalized biomaterial surface; said biomaterial comprising at least a first porous, biodegradable polymer portion that has an interconnected pore structure and that is degradable over a controllable time scale, wherein the polymer portion of the biomaterial is a poly(alpha-hydroxy acid), wherein the poly(alpha-hydroxy acid) is a polylactic acid polymer, a polyglycolic acid polymer or a polylactic-co-glycolic acid copolymer, and wherein the functionalization provides for specific control over the mineral coating on the biomaterial surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- chemical hydrolysis, electrolysis, or electromagnetic radiation; and
Specification