Sleep stage detection
First Claim
1. A method comprising, with one or more processors:
- receiving a biosignal that is indicative of activity within a brain of a patient;
determining a frequency characteristic of the biosignal;
determining a sleep stage of the patient based on the frequency characteristic of the biosignal, wherein the sleep stage occurs during a sleep state of the patient, the sleep state comprising a plurality of sleep stages; and
controlling a therapy module configured to be implanted in the patient to deliver deep brain electrical stimulation therapy to the brain of the patient during the sleep state based on the determined sleep stage, wherein controlling the therapy module to deliver deep brain electrical stimulation therapy comprises, in response to detecting a Stage 1 sleep stage, controlling the therapy module to deliver deep brain electrical stimulation therapy that improves performance of motor tasks by the patient relative to a patient state in which the patient is not receiving the deep brain electrical stimulation therapy, the motor tasks including initiating or maintaining movement.
1 Assignment
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Accused Products
Abstract
Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient. A frequency characteristic may include, for example, a power level within one or more frequency bands of the biosignal, a ratio of the power level in two or more frequency bands, or a pattern in the power level of one or more frequency bands over time. A therapy program may be selected or modified based on the sleep stage determination. Therapy may be delivered during the sleep stage according to the selected or modified therapy program. In some examples, therapy delivery may be controlled after making separate determinations of a sleep stage based on the biosignal and another physiological parameter, and confirming that the sleep stage determinations are consistent.
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Citations
62 Claims
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1. A method comprising, with one or more processors:
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receiving a biosignal that is indicative of activity within a brain of a patient; determining a frequency characteristic of the biosignal; determining a sleep stage of the patient based on the frequency characteristic of the biosignal, wherein the sleep stage occurs during a sleep state of the patient, the sleep state comprising a plurality of sleep stages; and controlling a therapy module configured to be implanted in the patient to deliver deep brain electrical stimulation therapy to the brain of the patient during the sleep state based on the determined sleep stage, wherein controlling the therapy module to deliver deep brain electrical stimulation therapy comprises, in response to detecting a Stage 1 sleep stage, controlling the therapy module to deliver deep brain electrical stimulation therapy that improves performance of motor tasks by the patient relative to a patient state in which the patient is not receiving the deep brain electrical stimulation therapy, the motor tasks including initiating or maintaining movement. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A system comprising:
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a therapy module configured to be implanted in a patient and deliver deep brain electrical stimulation therapy to a brain of the patient; a sensing module configured to sense a biosignal generated within the brain of the patient; and a processor configured to receive the biosignal from the sensing module, determine a frequency characteristic of the biosignal, determine a sleep stage of the patient based on the frequency characteristic of the biosignal, wherein the sleep stage occurs during a sleep state of the patient, the sleep state comprising a plurality of sleep stages, and control the therapy module to deliver deep brain electrical stimulation therapy to a target tissue site within the brain of the patient during the sleep state based on the determined sleep stage, wherein the processor is configured to control the therapy module to deliver the deep brain electrical stimulation therapy based on the determined sleep stage by at least, in response to detecting a Stage 1 sleep stage, controlling the therapy module to deliver deep brain electrical stimulation therapy that improves performance of motor tasks by the patient relative to a patient state in which the patient is not receiving the deep brain electrical stimulation therapy, the motor tasks including initiating or maintaining movement. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A system comprising:
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means for receiving a biosignal that is indicative of activity within a brain of a patient; means for determining a frequency characteristic of the biosignal; means for determining a sleep stage of the patient based on the frequency characteristic of the biosignal, wherein the sleep stage occurs during a sleep state of the patient, the sleep state comprising a plurality of sleep stages; and means for controlling an implantable therapy module to deliver deep brain electrical stimulation therapy to a target tissue site within the brain of the patient during the sleep state based on the determined sleep stage, the means for controlling comprising means for controlling the implantable therapy module to, in response to detection of a Stage 1 sleep stage by the means for determining, deliver deep brain electrical stimulation therapy that improves performance of motor tasks by the patient relative to a patient state in which the patient is not receiving the deep brain electrical stimulation therapy, the motor tasks including initiating or maintaining movement. - View Dependent Claims (59, 60)
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61. A non-transitory computer-readable medium comprising instructions that cause a processor to:
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receive a biosignal that is indicative of activity within a brain of a patient; determine a frequency characteristic of the biosignal; determine a sleep stage of the patient based on the frequency characteristic of the biosignal, wherein the sleep stage occurs during a sleep state of the patient, the sleep state comprising a plurality of sleep stages; and control an implantable therapy module to deliver deep brain electrical stimulation therapy to a target tissue site within the brain of the patient during the sleep state based on the determined sleep stage, wherein the instructions cause the processor to, in response to detecting a Sleep 1 sleep stage, control the implantable therapy module to deliver the deep brain electrical stimulation therapy that improves performance of motor tasks by the patient relative to a patient state in which the patient is not receiving the deep brain electrical stimulation therapy, the motor tasks including initiating or maintaining movement. - View Dependent Claims (62)
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Specification