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Prefilter system for biological systems

  • US 9,072,988 B2
  • Filed: 03/13/2008
  • Issued: 07/07/2015
  • Est. Priority Date: 03/19/2004
  • Status: Expired due to Fees
First Claim
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1. A tangential flow fluid (TFF) prefilter device for the selective upstream removal of non-specific binding constituents from a fluid stream containing protein during tangential flow fluid filtration, comprisingan inlet for receiving the protein containing fluid stream being purified;

  • a central distributor having two sides and in fluid communication with the inlet;

    one or more layers of porous filter media located on each side of the distributer and in fluid communication with the distributer, each layer of porous filter media having a different pore size range and containing one or more nonspecific binding agents, wherein the nonspecific binding agents are particle-based materials selected from the group consisting of fumed silica, glass, silica, silicates, controlled pore glass, and combinations thereof,a collection area in fluid communication with the porous filter media for receiving the protein containing fluid stream filtered through the media, andan outlet in fluid communication with collection area, such that at least a portion of the protein containing fluid steam passes through the porous filter media on each tangential flow pass.

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