Fluidic medical devices and uses thereof
First Claim
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1. An apparatus comprising:
- a plurality of adjacent reaction sites;
a sample collection unit, for introducing a biological fluid, in fluid communication with the plurality of adjacent reaction sites;
a plurality of reagent chambers, including a plurality of reagents, in fluid communication with said reaction sites,wherein each of said plurality of reaction sites comprise one or more reactants bound thereto for detecting an analyte; and
a system of fluidic channels to allow said biological fluid and said plurality of reagents to flow in said apparatus;
wherein at least one of said plurality of adjacent reaction sites is between two optical barriers, said two optical barriers comprise two non-linear channels configured to not allow photons to pass through the two non-linear channels and contaminate signals produced from the plurality of adjacent reaction sites;
walls of the at least one reaction site comprise optically opaque materials so that light will not escape said at least one reaction site through said walls, andthe two nonlinear channels provide fluid communication between the plurality of adjacent reaction sites.
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Abstract
This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.
203 Citations
17 Claims
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1. An apparatus comprising:
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a plurality of adjacent reaction sites; a sample collection unit, for introducing a biological fluid, in fluid communication with the plurality of adjacent reaction sites; a plurality of reagent chambers, including a plurality of reagents, in fluid communication with said reaction sites, wherein each of said plurality of reaction sites comprise one or more reactants bound thereto for detecting an analyte; and a system of fluidic channels to allow said biological fluid and said plurality of reagents to flow in said apparatus; wherein at least one of said plurality of adjacent reaction sites is between two optical barriers, said two optical barriers comprise two non-linear channels configured to not allow photons to pass through the two non-linear channels and contaminate signals produced from the plurality of adjacent reaction sites; walls of the at least one reaction site comprise optically opaque materials so that light will not escape said at least one reaction site through said walls, and the two nonlinear channels provide fluid communication between the plurality of adjacent reaction sites. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An apparatus comprising
a plurality of adjacent reaction sites; -
a sample collection unit, for introducing a biological fluid, in fluid communication with the plurality of adjacent reaction sites, wherein said plurality of adjacent reaction sites comprise a plurality of bound reactants for detecting an analyte; a plurality of reagent chambers, including a plurality of reagents, in fluid communication with said adjacent reaction sites; and a system of fluidic channels to allow said biological fluid and said plurality of reagents to flow in said apparatus; wherein at least one of said plurality of adjacent reaction sites is between two optical barriers, said two optical barriers comprise two non-linear channels configured to not allow photons to pass through the two non-linear channels and contaminate signals produced from the plurality of adjacent reaction sites; a wall of the at least one reaction site comprises an optically opaque material so that light will not escape said at least one reaction site through said walls, and the two nonlinear channels provide fluid communication between the plurality of adjacent reaction sites; wherein at least one of said adjacent reaction sites comprises a reaction surface with bound reactants around a center of the at least one reaction site and said bound reactants are spaced apart from said wall of the at least one reaction site by a concentric ring-shaped area, said at least one reaction site configured to reduce signal from any unbound conjugates remaining in the at least one reaction site. - View Dependent Claims (14, 15, 16, 17)
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Specification