Neural response system

• US 9,078,576 B2
• Filed: 05/30/2008
• Issued: 07/14/2015
• Est. Priority Date: 05/31/2007
• Status: Active Grant

• Current Assignee: Monash University
• Original Assignee: Monash University
• Inventors: Lithgow, Brian John
• Primary Examiner(s): BERHANU, ETSUB D
• Application Number:
  US12/602,456
• Publication Number:
  US 20100261978A1
• Time in Patent Office: 2,601 Days
• Field of Search: 600/544, 600/545
• US Class Current: 1/1
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/372 Analysis of electroencephalograms
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
• CPC Class Codes: A61B 5/6815 Ear
• CPC Class Codes: A61B 5/6838 Clamps or clips

Abstract

A neural response system, including a plurality of filters for each receiving and filtering a plurality of tilt response signals obtained from a person; a segmenter for segmenting the filtered response signals into time segments; and a neural event extractor for performing a neural event extraction process on each of the time segments to obtain and generate biomarker data representing a plurality of biomarkers for each segment.

Claims

1. A neural response system, including:

a plurality of different types of filters for each receiving and filtering a plurality of electrovestibulography response signals obtained from a person and generating a plurality of different types of filtered response signals based on the different types of filters;

a segmenter for receiving the plurality of different types of filtered response signals and for segmenting the filtered response signals into time segments;

a neural event extractor configured to receive each of the time segments and perform a neural event extraction process on each of the time segments to obtain and generate biomarker data representing a plurality of biomarkers for each segment; and

a diagnostic tool for comparing the biomarker data of each segment with fingerprint data for a condition, and recording deviation measures between the fingerprint data and the biomarker data to determine whether said person has said condition.

2. A neural response system as claimed in claim 1, wherein the plurality of filters are arranged and configured to receive the response signals obtained from at least one electrode configured to be connected to at least one ear of the person subjected to a plurality of tilt sequences in a tilt chair.

3. A neural response system as claimed in claim 1, wherein the filters include at least one of a notch filter to substantially pass all frequencies, a first high pass filter and a second high pass filter.

4. A neural response system as claimed in claim 3, wherein the cut-off frequency for the first high pass filter is about 5 Hz and the cut-off frequency for the second high pass filter is about 120 Hz.

5. A neural response systems as claimed in claim 1, wherein the neural event extractor generates curve data representing a Sp/Ap field potential curve for each segment.

6. A neural response system as claimed in claim 5, wherein the biomarker data is determined using the curve data and the biomarkers represent relationships and constants associated with the field potential curve.

7. A neural response system as claimed in claim 5, wherein the biomarker data is determined using the curve data and the biomarkers represent spike rates, and time and voltage measurements of the field potential curve.

8. A neural response system as claimed in claim 5, wherein the biomarker data is determined using the curve data and the biomarkers represent ratios, angles and areas associated with the field potential curve.

9. A neural response system as claimed in claim 1, wherein recording the deviations includes summing the deviations, and the diagnostic tool compares sums with the fingerprint data for the biomarkers.

10. A neural response system as claimed in claim 1, wherein the biomarkers represent a comparison between a background phase and an acceleration or deceleration phase of the response signals.

11. A neural response system as claimed in claim 1, including a tilt chair for subjecting the person to a plurality of tilt sequences, and at least one electrode configured to be connected to at least one ear of the person and an amplifier circuit to record the response signals produced in response to each tilt sequence.

12. A neural response system as claimed in claim 11, wherein the tilt sequences include at least one of up/down, front/back, ipsilateral, contralateral, and rotation.

13. A neural response system as claimed in claim 12, wherein the up/down and rotation sequences includes sequences with the patient upright and sequences with the person prone.

14. A neural response system as claimed in claim 13, wherein electrodes are configured to be connected to each ear of the person to record the response signals produced in response to each tilt sequence for the left ear and the right ear.

15. A neural response system as claimed in claim 1, wherein the biomarker data indicates whether the person has at least one condition being a neurological disorder and/or neurodegenerative disease.

16. A neural response system as claimed in claim 15, wherein the condition includes one of benign positional paroxysmal vertigo (BPPV), Meniere'"'"'s disease, Parkinson'"'"'s disease, Schizophrenia, depression, BiPolar Affective Disorder, Alzheimers, Dementia, Attention Deficit and Hyperactivity Disorder, Multiple Sclerosis, Huntington'"'"'s Chorea and Creutzfeldt Jakob disease.

17. A neural response system as claimed in claim 1, wherein the biomarker data indicates an effect arising from administration of a pharmaceutical and/or physical therapy.

18. A neural response system as claimed in claim 1, wherein the biomarker data differentiates between conditions having similar symptoms.

19. A neural response system as claimed in claim 18, wherein the conditions are benign positional paroxysmal vertigo (BPPV) and Meniere'"'"'s disease.

20. A neural response system as claimed in claim 18, wherein the conditions are clinical depression and a depressive phase of a BiPolar Affective Disorder.

21. A neural response process, including:

receiving and filtering, using a plurality of different types of filters, a plurality of electrovestibulography response signals obtained from a person to generate a plurality of different types of filtered response signals based on the different types of filters;

receiving the different types of filtered response signals at a segmenter, and segmenting the different types of filtered response signals into time segments using the segmenter;

receiving, at a neural event extractor, each of the time segments;

processing, using the neural event extractor, each of the time segments to obtain and generate biomarker data representing a plurality of biomarkers for each segment; and

comparing the biomarker data of each segment with fingerprint data for a condition, and recording deviation measures between the fingerprint data and the biomarker data to determine whether said person has said condition.

22. A neural response process as claimed in claim 21, wherein the response signals are obtained from at least one electrode connected to at least one ear of the person subjected to a plurality of tilt sequences in a tilt chair.

23. A neural response process as claimed in claim 22, wherein the tilt sequences include at least one of up/down, front/back, ipsilateral, contralateral, and rotation.

24. A neural response process as claimed in claim 23, wherein the up/down and rotation sequences includes sequences with the person upright and sequences with the person prone.

25. A neural response process as claimed in claim 24, including connecting electrodes to each ear of the person to record the response signals produced in response to each tilt sequence for the left ear and the right ear.

26. A neural response process as claimed in claim 21, wherein the filters include at least one of a notch filter to substantially pass all frequencies, a first high pass filter and a second high pass filter.

27. A neural response process as claimed in claim 26, wherein the cut-off frequency for the first high pass filter is about 5 Hz and the cut-off frequency for the second high pass filter is about 120 Hz.

28. A neural response process as claimed in claim 21, wherein said processing generates curve data representing a Sp/Ap field potential curve for each segment.

29. A neural response process as claimed in claim 28, wherein the biomarker data is determined using the curve data and the biomarkers represent relationships and constants associated with the field potential curve.

30. A neural response process as claimed in claim 28, wherein the biomarker data is determined using the curve data and the biomarkers represent spike rates, and time and voltage measurements of the field potential curve.

31. A neural response process as claimed in claim 28, wherein the biomarker data is determined using the curve data and the biomarkers represent ratios, angles and areas associated with the field potential curve.

32. A neural response process as claimed in claim 21, wherein recording the deviations includes summing the deviations, and the sums are compared with the fingerprint data for the biomarkers.

33. A neural response process as claimed in claim 21, wherein the biomarkers represent a comparison between a background phase and an acceleration or deceleration phase of the response signals.

34. A neural response process as claimed in claim 21, wherein the biomarker data indicates whether the person has at least one condition being a neurological disorder and/or neurodegenerative disease.

35. A neural response process as claimed in claim 34, wherein the condition includes one of benign positional paroxysmal vertigo (BPPV), Meniere'"'"'s disease, Parkinson'"'"'s disease, Schizophrenia, depression, BiPolar Affective Disorder, Alzheimers, Dementia, Attention Deficit and Hyperactivity Disorder, Multiple Sclerosis, Huntingdon'"'"'s Chorea and Creutzfeldt Jakob disease.

36. A neural response process as claimed in claim 21, wherein the biomarker data indicates an effect arising from administration of a pharmaceutical and/or physical therapy.

37. A neural response process as claimed in claim 21, wherein the biomarker data is used to differentiate a diagnosis between conditions having similar symptoms.

38. A neural response process as claimed in claim 37, wherein the conditions are benign positional paroxysmal vertigo (BPPV) and Meniere'"'"'s disease.

39. A neural response process as claimed in claim 37, wherein the conditions are clinical depression and a depressive phase of a BiPolar Affective Disorder.