Circuit for heartbeat detection and beat timing extraction

• US 9,078,577 B2
• Filed: 03/13/2013
• Issued: 07/14/2015
• Est. Priority Date: 12/06/2012
• Status: Active Grant

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: He, David Da, Sodini, Charles G.
• Primary Examiner(s): Stice, Paula J
• Application Number:
  US13/798,440
• Publication Number:
  US 20140163386A1
• Time in Patent Office: 853 Days
• Field of Search: 600508-509, 600/521
• US Class Current: 1/1
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/0255 Recording instruments specially adapted therefor
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/1102 Ballistocardiography
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/333 Recording apparatus specially adapted therefor
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: H03K 6/02 Amplifying pulses

Abstract

A circuit and method for long term electrocardiogram (ECG) monitoring is implemented with the goal of reducing power consumption, battery size, and consequently device size. In one embodiment, the integrated circuit includes an amplifier cell having a plurality of input terminals and an output terminal; a QRS amplifier cell in communication with the output of the amplifier cell; a baseline amplifier cell in communication with the output of the amplifier cell; a comparator cell having a first input terminal in communication with the output terminal of the QRS amplifier cell; and a V_DC cell having an input in communication with the output of the baseline amplifier cell and an output in communication with the second input terminal of the comparator cell, wherein the comparator cell generates an output pulse in response to the output signal from the amplifier cell and the output signal from the baseline amplifier cell.

Claims

1. A detection device for amplifying and detecting a periodic signal for storage, transmission, display or processing, the detection device comprising:

a preamplifier cell having a plurality of input terminals and an output terminal, the preamplifier cell amplifying the periodic signal presented at one or more of its input terminals to form a first amplified periodic signal;

a signal amplifier cell having an input terminal and an output terminal, the input terminal of the signal amplifier cell in communication with the output terminal of the preamplifier cell, the signal amplifier cell amplifying the first amplified periodic signal presented at its input terminal, the signal amplifier having a bandwidth sufficient to form a filtered amplified periodic signal preserving the highest frequency pulsatile periodic features of the first amplified periodic signal;

a baseline amplifier cell having an input terminal and an output terminal, the input terminal of the baseline amplifier cell in communication with the output terminal of the preamplifier cell, the baseline amplifier amplifying the first amplified periodic signal presented at its input terminal and having a bandwidth sufficient to form a baseline signal that preserves a baseline voltage while removing the periodic features of the first amplified periodic signal;

a comparator cell having a first input terminal and a second input terminal and an output terminal, the first input terminal of the comparator cell in communication with the output terminal of the signal amplifier cell; and

a V_DC cell having a first terminal in communication with the output terminal of the baseline amplifier cell and an output terminal in communication with the second input terminal of the comparator cell, the V_DC cell adding a DC offset to the baseline signal to form an offset baseline signal at its output terminal,

wherein the comparator cell generates an output signal in response to the filtered amplified periodic signal from the signal amplifier cell and the offset baseline signal from the V_DC cell, the comparator cell output signal comprising a plurality of pulses corresponding to peaks in the periodic signal.

2. The detection device of claim 1, wherein the signal at the input of the preamplifier cell is one of a PPG, a BCG and a respiration signal.

3. The detection device of claim 1, wherein the signal amplifier cell is a QRS amplifier cell.

4. The detection device of claim 1,

wherein the V_DC cell has a second input terminal, and

wherein the device further comprises;

a microcontroller cell having an input terminal in communication with the output terminal of the comparator cell and an output terminal in communication with the second input terminal of the V_DC cell.

5. The detection device of claim 1, wherein the preamplifier cell is a PGA amplifier.

6. A method for amplifying and detecting a periodic physiological signal comprising the steps of:

amplifying a signal from a physiological signal source using a first amplifier to form a first amplified signal;

amplifying the first amplified signal with a second amplifier having a bandwidth sufficient to form a filtered first amplified signal preserving the with highest frequency pulsatile periodic features of the first amplified signal;

amplifying the first amplified signal with a third amplifier having a bandwidth sufficient to form a baseline signal that preserves a baseline voltage while removing the periodic features of the physiological signal;

adding a DC offset to the baseline signal to form an offset baseline signal using an adder;

comparing the filtered amplified signal to the offset baseline signal using a comparator; and

generating an output signal if the filtered amplified signal is greater than the offset baseline, the output signal comprising a plurality of pulses corresponding to peaks in the periodic physiological signal for storage, transmission, display or processing.

7. The method of claim 6, wherein the bandwidth of the third amplifier is 1 Hz.

8. The method of claim 6, wherein the bandwidth of the third amplifier is 0.05 Hz.

9. The method of claim 6, further comprising adjusting the amplification value of the preamplifier of the signal from the physiological signal source.

10. The method of claim 6, wherein the timing of an R-wave in the QRS signal is estimated in response to measuring the midpoint timing of the corresponding output pulse signal.

11. The method of claim 6, wherein the signal source is an ECG sensor, and the first amplified signal is an amplified ECG signal.

12. The method of claim 11, wherein the amplified ECG signal is amplified by the third amplifier having a bandwidth of 1 Hz to generate the baseline signal.

13. The method of claim 11, wherein the amplified ECG signal is amplified by the second amplifier having a bandwidth of 20-40 Hz to form a QRS signal.

14. The method of claim 13, further comprising selecting the offset baseline comprising the steps of:

a. determining the peak voltage of an R-wave of the QRS signal;

b. determining a baseline DC offset; and

c. calculating one half the difference between the baseline DC offset and peak voltage of the R-wave and adding the baseline DC offset to obtain the offset baseline.

15. The method of claim 13, wherein the QRS signal is compared to the baseline signal offset by a DC offset to form an offset baseline signal.

16. The method of claim 15, further comprising selecting the DC offset comprising the steps of:

a. setting the DC offset to a predetermined value;

b. comparing the filtered amplified ECG signal to the sum of the baseline signal and the DC offset to produce the output signal;

c. if the output signal is not a series of regularly spaced pulses of 40 ppm to 180 ppm then incrementing the DC offset;

d. iteratively repeating steps b and c until the output signal is a series of regularly spaced pulses of 40 ppm to 180 ppm; and

e. setting the DC offset at the value of the DC offset that produces the regularly spaced output signal pulses of 40 ppm to 180 ppm.