Apparatus for non-invasive optical monitoring

• US 9,078,617 B2
• Filed: 03/12/2009
• Issued: 07/14/2015
• Est. Priority Date: 03/17/2008
• Status: Active Grant

• Current Assignee: OrNim Medical, Ltd. (OrNim, Inc.)
• Original Assignee: OrNim Medical, Ltd. (OrNim, Inc.)
• Inventors: Pintel, Ofer, Breskin, Ilan, Metzger, Yaakov, Shechter, Revital Pery, Bendkowski, Michael
• Primary Examiner(s): EVOY, NICHOLAS LANE
• Application Number:
  US12/402,582
• Publication Number:
  US 20090234228A1
• Time in Patent Office: 2,315 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/08 Sensors provided with means for identification, e.g. barcodes or memory chips
• CPC Class Codes: A61B 5/0097 by applying acoustic waves and detecting light, i.e. acoustooptic measurements
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61B 8/42 Details of probe positioning or probe attachment to the patient
• CPC Class Codes: A61B 8/4236 characterised by adhesive patches
• CPC Class Codes: A61B 8/4281 characterised by sound-transmitting media or devices for coupling the transducer to the tissue
• CPC Class Codes: A61B 8/4438 Means for identifying the diagnostic device, e.g. barcodes
• CPC Class Codes: A61B 8/4472 Wireless probes

Abstract

A probe assembly is presented for use in monitoring one or more parameters of a subject. The probe assembly comprises: an acoustic port for transmitting acoustic radiation into a region of interest in the subject, at least one light output port for transmitting incident light towards the region of interest, at least one light input port for receiving light returned from the subject, and a control utility integrated in the probe assembly, said control utility being configured for controlling at least one condition of a monitoring procedure and enabling the monitoring procedure upon detecting that said at least one condition is satisfied.

Claims

1. A probe assembly for use in monitoring one or more parameters of a subject, the probe assembly comprising:

an acoustic port for transmitting acoustic radiation into a region of interest in the subject,

at least one light output port for transmitting incident light towards the region of interest,

at least one light input port for receiving light returned from the subject; and

a control utility, wherein said control utility is integrated in the probe assembly and is configured for automatically controlling a monitoring procedure so as to start the monitoring procedure upon identifying that at least one predetermined condition of the monitoring procedure is satisfied and to stop the monitoring procedure upon identifying that at least one predetermined condition of the monitoring procedure is not satisfied, said control utility comprising at least one of the following;

(i) a coding chip adapted for communication with an external controller, the coding chip being adapted for generating an activation code to be identified by the external controller, such that identification of the activation code generated by the coding chip of the probe assembly is a condition to allow operation of said probe assembly, and

(ii) a safety system comprising a sensor configured for sensing whether at least one safety condition of the monitoring procedure is satisfied, and an actuator configured to enable or disable the monitoring procedure in response to a sensing indication produced by said sensor depending on said at least one safety condition.

2. The probe assembly of claim 1, wherein the control utility further comprises a memory unit adapted for recording data indicative of measurements taken on a specific subject during a certain period of time, thereby enabling use of said data as a measurement history of the specific subject, the measurements being taken by one or more of the probe assemblies.

3. The probe of claim 1, wherein the sensing system is adapted for sensing a degree of attachment between the probe assembly and the subject, said degree of attachment being indicative of the at least one safety condition relating to the degree of coupling between the subject and at least one of said acoustic and light ports.

4. The probe assembly of claim 1, being configured as a two-part device comprising a first probe body unit and a second unit, wherein said second unit interfaces with the subject when the probe assembly is put in operation.

5. The probe assembly of claim 4, wherein the first probe body unit and the second unit are configured such that the second unit is attachable to and detachable from the first probe body unit.

6. The probe assembly of claim 5, wherein said second unit carries at least a part of the control utility.

7. The probe assembly of claim 6, wherein said second unit carries a memory unit, the memory unit being adapted for recording data indicative of measurements taken on a specific subject during a certain period of time, enabling use of said data as a measurement history of the specific subject, the measurements being taken by one or more of the probe assemblies.

8. The probe assembly of claim 4, wherein the second unit comprises an adhesive media.

9. The probe assembly of claim 4, wherein the first probe body unit comprises the acoustic port, the at least one light output port, and the at least one light input port.

10. The probe assembly of claim 4, wherein the second unit interfaces an output surface of the first unit through which acoustic and light radiations are transmitted in between the probe assembly and the subject.

11. The probe assembly of claim 8, wherein the second unit interfaces an output surface of the first unit and transmits acoustic and light radiation therethrough towards and from the subject.

12. The probe assembly of claim 11, wherein said second unit is configured as a flexible cover on an output surface of the first unit.

13. The probe assembly of claim 8, wherein said adhesive media comprises an ultrasound-skin coupling pad comprising one or more materials selected to provide desired acoustic coupling between the acoustic port and the subject and being substantially transparent for a wavelength range used in the probe.

14. The probe assembly of claim 1, further comprising an ultrasound-skin coupling pad comprising one or more materials selected to provide desired acoustic coupling between the acoustic port and the subject.

15. The probe assembly of claim 14, wherein said ultrasound-skin coupling pad is substantially transparent to light of a predetermined wavelength range.

16. The probe assembly of claim 14, wherein said ultrasound-skin coupling pad has acoustic impedance similar to that of tissue or skin of the subject.

17. The probe assembly of claim 14, wherein said ultrasound-skin coupling pad has a matrix that is a polymerization product of a suspension of elastomeric resin in a plasticizer.

18. The probe assembly of claim 14, wherein said ultrasound-skin coupling pad is electrically insulating.

25. The probe assembly of claim 1, wherein said safety system is configured and operable for controlling the at least one condition of the monitoring procedure, said at least one condition comprising at least one of the following:

existence of a contact between the probe assembly and the subject;

a degree of coupling between the subject and at least one of said acoustic and light ports; and

positioning of the probe assembly in a docking station.

19. A probe assembly for use in monitoring one or more parameters of a subject, the probe assembly being configured as a two-part device comprising first and second units, wherein:

the first unit is configured as a probe body unit and comprises an acoustic port for transmitting acoustic radiation into a region of interest in the subject, at least one light output port for transmitting incident light towards the region of interest, at least one light input port for receiving light returned from the subject,

the second unit comprises an adhesive assembly interfaces with the subject when the probe assembly is put in operation, the second unit is attachable to and detachable from the first unit and comprises an electronic unit having a memory utility adapted for recording data indicative of measurements taken on a specific subject during a certain period of time, enabling use of said data as a measurement history of the specific subject, the recorded data corresponding to the measurements being taken by one or more of the probe assemblies.

20. The probe assembly of claim 19, further comprising at least one of the following:

(i) a coding chip configured to generate an activation code that allows operation of said probe assembly; and

(ii) a sensing system comprising a sensor configured for sensing and determining a degree of coupling between the subject and at least one of said acoustic and light ports and an actuator for selectively enabling and disabling the monitor procedure depending on the determined degree of coupling.

21. The probe assembly of claim 20, wherein at least one of said coding chip and said sensing system is at least partially located in the first unit.

22. A monitoring system for monitoring one or more parameters of a subject, the monitoring system comprising:

at least one probe assembly, the probe assembly comprising;

an acoustic port for transmitting acoustic radiation into a region of interest in the subject, at least one light output port for transmitting incident light towards the region of interest, at least one light input port for receiving light returned from the subject, and a control utility integrated in the probe assembly and,

a controller which is external to said at least one probe assembly and is in communication with the control utility integrated in the probe assembly;

wherein said control utility is configured and operable to carry out at least one of the following;

(i) recording data indicative of measurements taken on the specific subject during a certain period of time;

(ii) communicating with the external controller using generation of an activation code enabling said controller to identify the probe assembly such that identification of the activation code is a condition to allow operation of said at least one probe assembly; and

(iii) sensing at least a degree of attachment between the probe assembly and the subject and enabling operation of the probe assembly upon identifying that said degree of attachment satisfies a predetermined safety condition.

23. The system of claim 22, comprising at least two of the probe assemblies.

24. The system of claim 23, wherein the control utility of each of the at least two probe assemblies is adapted for storing data indicative of results of measurements taken by all the probe assemblies.