Methods for treating headache

• US 9,078,893 B2
• Filed: 10/23/2008
• Issued: 07/14/2015
• Est. Priority Date: 02/26/2004
• Status: Active Grant

• Current Assignee: Allergan Incorporated (Abbvie Incorporated)
• Original Assignee: Allergan Incorporated (Abbvie Incorporated)
• Inventors: Turkel, Catherine C., Brin, Mitchell F.
• Primary Examiner(s): Minnifield, Nita M
• Application Number:
  US12/256,655
• Publication Number:
  US 20090263426A1
• Time in Patent Office: 2,455 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 38/4893 Botulinum neurotoxin (3.4.24.69)
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/06 Antimigraine agents
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/30 for treating abuse or dependence
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C12Y 304/24069 Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin

Abstract

A headache can be treated effectively by administration of a botulinum toxin to a patient at specific muscles using specific doses.

Claims

1. A method for reducing the occurrence of or alleviating a headache in a patient with chronic migraine headaches, the method comprising local administration by injection of a composition comprising a botulinum toxin type A, wherein the number of injection sites is 23 to 58, the number of muscle areas injected is 6 to 7 and the botulinum toxin type A dose is 105 to 260 units, and wherein at least the frontal/glabellar, occipitalis, temporalis, semispinalis, splenius capitis and trapezius muscles are injected.

2. The method of claim 1, wherein the administration is subdermal or subcutaneous.