Devices and methods for selectively lysing cells

• US 9,079,001 B2
• Filed: 03/13/2013
• Issued: 07/14/2015
• Est. Priority Date: 12/02/2005
• Status: Active Grant

• Current Assignee: Ulthera Inc. (Merz Pharma GmbH & Company Kgaa)
• Original Assignee: Ulthera Inc. (Merz Pharma GmbH & Company Kgaa)
• Inventors: Merchant, Adnan I., Deem, Mark E.
• Primary Examiner(s): PHAN, THAI Q
• Application Number:
  US13/799,377
• Publication Number:
  US 20130197427A1
• Time in Patent Office: 853 Days
• Field of Search: 703/11, 703/12, 604/22, 604/24, 604/173, 601/2, 601/17
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/006 for gases, e.g. CO2
• CPC Class Codes: A61M 2005/1585 Needle inserters
• CPC Class Codes: A61M 2005/1655 Filter with fibers, e.g. filtering element in form of hollow fibers
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/158 Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
• CPC Class Codes: A61M 5/165 Filtering accessories, e.g. blood filters, filters for infusion liquids A61M1/14 , A61M1/34, A61M1/3627, A61M1/3679, A61M1/3687 take precedence; needle sets with incorporated air inlet filters A61M5/162
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/445 the media being heated in the reservoir, e.g. warming bloodbags
• CPC Class Codes: G06Q 10/02 Reservations, e.g. for tickets, services or events
• CPC Class Codes: G06Q 10/06 Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling

Abstract

A device for generating microbubbles in a gas and liquid mixture and injection device, the device comprising: a housing defining a mixing chamber; means for mixing solution contained in the mixing chamber to generate microbubbles in the solution; a needle array removably attached to the housing and in fluid connection with the mixing chamber, the needle array including at least one needle; and at least one pressure sensor for measuring tissue apposition pressure, the pressure sensor being mounted on one of the housing and the needle array.

Claims

1. A device for generating microbubbles in a gas and liquid mixture and injection device, said device comprising:

a housing defining a mixing chamber and mixing a solution contained in said mixing chamber to generate microbubbles in the solution;

a needle array removably attached to the housing and in fluid connection with said mixing chamber, said needle array including

a plurality of non-vibrating solution injection needles operably connected to the mixing chamber, said solution injection members needles being substantially equally spaced apart and configured to percutaneously inject the microbubble solution into a treatment area located in a subcutaneous tissue between 3 mm and 15 mm below the dermis; and

at least one pressure sensor for measuring tissue apposition pressure, said pressure sensor being mounted on one of the housing and the needle array,

wherein the device is configured to infuse a substantially uniform distribution of the microbubble solution in the treatment area, and wherein the microbubble solution is configured to produce subcutaneous cavitational bioeffects in the treatment area without significant thermal effects to the subcutaneous tissue and the dermis when subjected to unfocused acoustic waves from a point above and external to the dermis.

2. The device of claim 1, further comprising:

a deployment means,

wherein deployment of said needles is inhibited if a measured apposition pressure value falls beneath an initial threshold value or exceeds a secondary threshold value.

3. The device of claim 1, further comprising:

a deployment means; and

,

two pressure sensors, wherein deployment of said needles is inhibited if a difference in measured apposition pressure values between any two sensors exceeds a threshold value.

4. The device of claim 3, wherein deployment of said needles is inhibited if a measured apposition pressure values falls beneath an initial threshold value or exceeds a secondary threshold value.

5. The device of claim 1, wherein said needles comprise a needle having a through-bore, the needle having a texture.