Physiological signal amplifier with voltage protection and fast signal recovery

• US 9,079,036 B2
• Filed: 07/08/2013
• Issued: 07/14/2015
• Est. Priority Date: 03/30/2009
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Wanasek, Kevin A.
• Primary Examiner(s): DIETRICH, JOSEPH M
• Application Number:
  US13/936,241
• Publication Number:
  US 20130296974A1
• Time in Patent Office: 736 Days
• Field of Search: 607/28, 607/36, 607/37
• US Class Current: 1/1
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/308 for electrocardiography [ECG]
• CPC Class Codes: A61N 1/37 Monitoring; Protecting
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control

Abstract

A physiological sense amplifier achieves fast recovery times following receipt of a large voltage, such as when a defibrillation pulse is delivered, without blanking. The recovery time may be less than one millisecond when polarization of surrounding tissue or the housing of the device is not present. The sense amplifier uses a feedback network to clamp the input voltage to a gain amplifier at a predetermined value when a predetermined threshold value is exceeded.

Claims

1. A subcutaneous medical device comprising:

a first electrode;

a sense amplifier configured to sense a physiological electrical signal of a patient subsequent to delivery of a stimulation therapy through the first electrode without blanking; and

a processor configured to process the sensed physiological electrical signal;

wherein the sense amplifier includes a gain amplifier, a high pass filter, and a feedback network having a transistor coupled to the high pass filter, the feedback network being configured to clamp an input voltage to the gain amplifier at a predetermined threshold value responsive to the input voltage exceeding the predetermined threshold value.

2. The subcutaneous medical device of claim 1, wherein the high pass filter includes a capacitor, the high pass filter being coupled to the gain amplifier, wherein the feedback network is operable to clamp the input voltage based on coupling of the high pass filter to a resistive current path for selective discharging or charging of the capacitor.

3. The subcutaneous medical device of claim 1, wherein the high pass filter comprises a resistor electrically-coupled to a capacitor and operatively configured having a cutoff frequency for filtering direct current signals and passing the physiological electrical signal.

4. The subcutaneous medical device of claim 1, wherein the transistor of the feedback network is coupled in parallel with the high pass filter,

wherein the output voltage of the amplifier is coupled to a control terminal of the transistor to activate the transistor responsive to the input voltage exceeding the predetermined threshold value, and

wherein the transistor clamps the input voltage of the amplifier responsive to the transistor being activated.

5. The subcutaneous medical device of claim 4, wherein the predetermined threshold value is a function of a control terminal to reference terminal threshold value of the transistor.

6. The subcutaneous medical device of claim 4, wherein, a pole of the high pass filter is shifted responsive to activation of the transistor.

7. The subcutaneous medical device of claim 1, wherein the sense amplifier is configured to sense the physiological electrical signal immediately subsequent to delivery of the stimulation therapy.

8. The subcutaneous medical device of claim 1, wherein the sense amplifier is configured to sense the physiological electrical signal within 1 millisecond following delivery of the stimulation therapy.

9. The subcutaneous medical device of claim 1, wherein the processor controls the sense amplifier for selective operation in a first mode and a second mode, such that the feedback network is inactivated during operation of the sense amplifier in the first mode responsive to the input voltage being less than the predetermined threshold voltage and the feedback network is activated during operation of the sense amplifier in the second mode responsive to the input voltage being greater than the predetermined threshold voltage.

10. The subcutaneous medical device of claim 1, wherein the predetermined threshold voltage is selected having a voltage ranging between a physiological signal voltage and a stimulation therapy voltage.

11. The subcutaneous medical device of claim 1, wherein the predetermined threshold voltage is selected having a voltage ranging between 20 millivolts and 1 volt.

12. The subcutaneous medical device of claim 1, wherein the predetermined threshold voltage is selected to increase a signal-to-noise ratio of the sensed physiological electrical signal.

13. The subcutaneous medical device of claim 1, wherein the input voltage exceeds the predetermined threshold value responsive to delivery of stimulation therapy to the patient, and

wherein the sense amplifier has a recovery time of less than approximately one millisecond following delivery of the electrical stimulation.

14. The subcutaneous medical device of claim 1, wherein the clamped input voltage is approximately zero volts.

15. The subcutaneous medical device of claim 1, further comprising a time delay unit coupled to the feedback network and configured to activate the clamping of the feedback network for a predetermined duration.

16. The subcutaneous medical device of claim 15, wherein the feedback network includes a transistor and the time delay unit applies a voltage to a control terminal of the transistor for predetermined duration subsequent to activation of the transistor.

17. The subcutaneous medical device of claim 15, wherein the time delay unit comprises a resistor and a capacitor.

18. The subcutaneous medical device of claim 1, further comprising a time delay unit coupled to the feedback network and configured to activate the clamping of the feedback network for a predetermined duration.

19. A subcutaneous medical device comprising:

a first electrode;

a sense amplifier coupled to the first electrode and configured to sense a physiological electrical signal through the first electrode without blanking, wherein the first electrode delivers a stimulation therapy prior to the sensing of the physiological electrical signal; and

a processor configured to process the sensed physiological electrical signal, wherein the sense amplifier includes a gain amplifier and a feedback network configured to clamp an input voltage to the gain amplifier at a predetermined threshold value immediately subsequent to delivery of the stimulation therapy.

20. A subcutaneous medical device comprising:

a first electrode;

a sense amplifier operable in a first mode and a second mode and including a transistor coupled to a resistor, the sense amplifier being coupled to the first electrode to receive a sensed physiological electrical signal, wherein the sense amplifier is operable in the first mode responsive to an input to the sense amplifier being less than a predetermined threshold value and in the second mode responsive to the input to the sense amplifier being greater than the predetermined threshold value; and

a processor configured to process the sensed physiological electrical signal, wherein the input to the sense amplifier is clamped at the predetermined threshold value in the second mode.