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Culturing human embryonic stem cells with a noggin to generate cells lacking Pax-6 expression

  • US 9,080,147 B2
  • Filed: 01/30/2009
  • Issued: 07/14/2015
  • Est. Priority Date: 06/20/2000
  • Status: Expired due to Term
First Claim
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1. A method of preventing neuroectoderm differentiation of human embryonic stem (ES) cells, said method comprising culturing human ES cells in the presence of a noggin which is a direct antagonist of a BMP-2 mediated default pathway of extraembryonic endoderm differentiation, wherein a concentration of said noggin is in the range of 100 to 500 ng/ml to generate a population of differentiated cells that do not express Pax-6, thereby preventing neuroectoderm differentiation of human ES cells.

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