Carriers having biological substance
First Claim
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1. A method for producing a fiber alignment slice having coordinates for each fiber unit thereof, comprising:
- (aa) longitudinally binding together a plurality of fibers, each of which has had one type of biological substance immobilized to it to form a fiber alignment;
(a) sequentially cutting the fiber alignment to obtain a series of m fiber alignment slices S(1), S(2), . . . S(h), . . . S(m);
(b) selecting any given slice S(h) from m number of slices and determining two-dimensional coordinates for each fiber unit contained in slice S(h) from coordinate reference points provided on slice S(h);
(c) determining the two-dimensional coordinates of each fiber unit contained in another slice of the same fiber alignment S(i) based on the two dimensional coordinates determined for slice S(h) in step (b) and the coordinate reference points in said slice S(i) and recording said coordinates on a computer readable medium, wherein slice S(i) is close enough to slice S(h) to permit interpolation of the coordinates of any intervening slices from the coordinates determined for S(h) and S(i); and
(d) repeating steps (b) and (c) to determine the two-dimensional coordinates of each fiber unit in other members of the series of fiber alignment slices;
wherein the fiber alignment of (aa) when sequentially sliced produces a fiber alignment slice on which the one type of biological substance immobilized in or on each fiber of the fiber alignment slice is accessible to binding by a ligand for that biological substance;
wherein said one type of biological substance is immobilized inside of or on a porous fiber prior to longitudinally binding the fibers together.
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Abstract
The present invention relates to biological substance-immobilized fibers wherein a biological substance is immobilized on a fiber, fibers retaining a biological substance-immobilized gel, and fiber alignments having bundles of the above-described fibers and slices of the same.
21 Citations
25 Claims
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1. A method for producing a fiber alignment slice having coordinates for each fiber unit thereof, comprising:
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(aa) longitudinally binding together a plurality of fibers, each of which has had one type of biological substance immobilized to it to form a fiber alignment; (a) sequentially cutting the fiber alignment to obtain a series of m fiber alignment slices S(1), S(2), . . . S(h), . . . S(m); (b) selecting any given slice S(h) from m number of slices and determining two-dimensional coordinates for each fiber unit contained in slice S(h) from coordinate reference points provided on slice S(h); (c) determining the two-dimensional coordinates of each fiber unit contained in another slice of the same fiber alignment S(i) based on the two dimensional coordinates determined for slice S(h) in step (b) and the coordinate reference points in said slice S(i) and recording said coordinates on a computer readable medium, wherein slice S(i) is close enough to slice S(h) to permit interpolation of the coordinates of any intervening slices from the coordinates determined for S(h) and S(i); and (d) repeating steps (b) and (c) to determine the two-dimensional coordinates of each fiber unit in other members of the series of fiber alignment slices; wherein the fiber alignment of (aa) when sequentially sliced produces a fiber alignment slice on which the one type of biological substance immobilized in or on each fiber of the fiber alignment slice is accessible to binding by a ligand for that biological substance; wherein said one type of biological substance is immobilized inside of or on a porous fiber prior to longitudinally binding the fibers together. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for producing a contiguous series of sliced two-dimensional arrays that each have reference coordinates that can be aligned with reference coordinates of adjacent sliced two dimensional arrays, comprising:
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(a) binding together a plurality of longitudinal fibers around a fiber axis at a density of 100 or more fibers per cross-sectional cm2 to form a bundle of longitudinal fibers aligned around a fiber axis;
wherein said bundle of fibers includes at least two marker fibers that provide coordinate reference points;(b) sequentially cutting the bundle of longitudinal fibers aligned around a fiber axis across the fiber axis to form a numbered contiguous series of cross-sectional arrays that represent slices of the bundle of longitudinal fibers and which are denoted S(1), S(2) . . . S(h) . . . S(m), wherein each array contains coordinate reference points that are cross-sections of the at least two marker fibers; (c) selecting an array S(h) between array S(1) and S(m) and determining the two-dimensional coordinates for each fiber cross-section contained in array S(h) in relation to the coordinate reference points in array S(h) and recording the positions of the coordinate reference points for array S(h) on a computer readable medium; (d) selecting an array S(i) between arrays S(h) and S(m) and determining the two-dimensional coordinates for each fiber cross-section contained in array S(i) in relation to the coordinate reference points in array S(i) and recording the positions of the coordinate reference points for array S(i) on a computer readable medium;
wherein slice S(i) is close enough to array S(h) to permit interpolation of the coordinates of any intervening arrays from the coordinates determined for S(h) and S(i);(e) determining the two-dimensional coordinates of each fiber cross-section contained in array S(i) based on the coordinate reference points in array S(h); (f) repeating steps (d) and (e) to determine the two-dimensional coordinates of additional arrays S(i) between arrays S(h) and S(m) of said fiber bundle based on the coordinate reference points in array S(h), thereby providing a contiguous series of two-dimensional arrays that each have reference coordinates that are aligned with reference coordinates of an adjacent two dimensional array and which permit alignment of the cross-sections of each array, which are obtained from the same fiber, in different arrays. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification
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Current AssigneeMitsubishi Chemical Corporation (Mitsubishi Chemical Group Corp.)
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Original AssigneeMitsubishi Rayon Company Limited (Mitsubishi Chemical Holdings Corporation)
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InventorsIshimaru, Teruta
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Primary Examiner(s)Sisson, Bradley L
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Application NumberUS11/514,162Publication NumberTime in Patent Office3,238 DaysField of SearchNoneUS Class Current1/1CPC Class CodesD06M 15/13 Alginic acid or derivatives...D06M 15/15 Proteins or derivatives the...D06M 15/263 of unsaturated carboxylic a...D06M 15/285 of unsaturated carboxylic a...D06M 15/333 of vinyl acetate; Polyvinyl...D06M 15/3562 containing nitrogenD06M 15/53 Polyethers polyacetals D06M...D06M 16/00 Biochemical treatment of fi...D06M 23/00 Treatment of fibres, thread...D06M 23/02 Processes in which the trea...Y10T 156/1052 with cutting, punching, tea...Y10T 436/143333 Saccharide [e.g., DNA, etc.]
