Method and system for patient-specific modeling of blood flow
First Claim
1. A method for determining cardiovascular information for a patient, comprising:
- generating a patient-specific anatomical model of a patient'"'"'s coronary arteries and heart from 4D medical image data of the patient, by generating a 4D geometric model of the patient'"'"'s coronary arteries from the 4D medical image data by segmenting the coronary arteries and generating a geometric surface model for the segmented coronary arteries in each of a plurality of frames of the 4D medical image data, and generating a 4D anatomical model of the patient'"'"'s heart from the 4D medical image data, wherein the 4D medical image data comprises three spatial dimensions and a time dimension;
generating a multi-scale functional model of coronary circulation based on the patient-specific anatomical model, wherein the multi-scale functional model comprises a 3D computation model and at least one reduced order model; and
simulating blood flow in at least one stenosis region of at least one coronary artery using the multi-scale functional model of coronary circulation.
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Abstract
Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient'"'"'s heart, and create a three-dimensional model representing at least a portion of the patient'"'"'s heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient'"'"'s heart and determine a fractional flow reserve within the patient'"'"'s heart based on the three-dimensional model and the physics-based model.
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Citations
28 Claims
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1. A method for determining cardiovascular information for a patient, comprising:
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generating a patient-specific anatomical model of a patient'"'"'s coronary arteries and heart from 4D medical image data of the patient, by generating a 4D geometric model of the patient'"'"'s coronary arteries from the 4D medical image data by segmenting the coronary arteries and generating a geometric surface model for the segmented coronary arteries in each of a plurality of frames of the 4D medical image data, and generating a 4D anatomical model of the patient'"'"'s heart from the 4D medical image data, wherein the 4D medical image data comprises three spatial dimensions and a time dimension; generating a multi-scale functional model of coronary circulation based on the patient-specific anatomical model, wherein the multi-scale functional model comprises a 3D computation model and at least one reduced order model; and simulating blood flow in at least one stenosis region of at least one coronary artery using the multi-scale functional model of coronary circulation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for determining cardiovascular information for a patient, comprising:
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generating a patient-specific anatomical model of a patient'"'"'s coronary arteries and heart from 4D medical image data of the patient, by generating a 4D geometric model of the patient'"'"'s coronary arteries from the 4D medical image data, and generating a 4D anatomical model of the patient'"'"'s heart from the 4D medical image data by extracting individual models of each of a plurality of heart components in each of a plurality of frames of the 4D medical image data; and
integrating the individual models for the plurality of heart components in each of the plurality of frames of the 4D medical image data by establishing mesh point correspondence between the individual models, wherein the 4D medical image data comprises three spatial dimensions and a time dimension;generating a multi-scale functional model of coronary circulation based on the patient-specific anatomical model, wherein the multi-scale functional model comprises a 3D computation model and at least one reduced order model; and simulating blood flow in at least one stenosis region of at least one coronary artery using the multi-scale functional model of coronary circulation.
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21. An apparatus comprising at least one computer system containing computer-executable programming instructions for performing a method for determining patient-specific cardiovascular information, the method comprising:
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generating a patient-specific anatomical model of a patient'"'"'s coronary arteries and heart from 4D medical image data of the patient, by generating a 4D geometric model of the patient'"'"'s coronary arteries from the 4D medical image data, and generating a 4D anatomical model of the patient'"'"'s heart from the 4D medical image data by extracting individual models of each of a plurality of heart components in each of a plurality of frames of the 4D medical image data; and
integrating the individual models for the plurality of heart components in each of the plurality of frames of the 4D medical image data by establishing mesh point correspondence between the individual models, wherein the 4D medical image data comprises three spatial dimensions and a time dimension;generating a multi-scale functional model of coronary circulation based on the patient-specific anatomical model, wherein the multi-scale functional model comprises a 3D computation model and at least one reduced order model; and simulating blood flow in at least one stenosis region of at least one coronary artery using the multi-scale functional model of coronary circulation. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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28. An apparatus comprising at least one computer system containing computer-executable programming instructions for performing a method for determining patient-specific cardiovascular information, the method comprising:
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generating a patient-specific anatomical model of a patient'"'"'s coronary arteries and heart from 4D medical image data of the patient, by generating a 4D geometric model of the patient'"'"'s coronary arteries from the 4D medical image data by segmenting the coronary arteries and generating a geometric surface model for the segmented coronary arteries in each of a plurality of frames of the 4D medical image data, and generating a 4D anatomical model of the patient'"'"'s heart from the 4D medical image data, wherein the 4D medical image data comprises three spatial dimensions and a time dimension; generating a multi-scale functional model of coronary circulation based on the patient-specific anatomical model, wherein the multi-scale functional model comprises a 3D computation model and at least one reduced order model; and simulating blood flow in at least one stenosis region of at least one coronary artery using the multi-scale functional model of coronary circulation.
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Specification