Placental tissue grafts and methods of preparing and using the same
First Claim
1. A tissue graft comprising:
- a first membrane comprising modified amnion wherein the modified amnion has a first side which is an exposed basement membrane and a second side which is a fibroblast layer; and
one or more additional membranes laminated to the first membrane,wherein the one or more additional membranes is selected from the group consisting of amnion, chorion, allograft pericardium, allograft acellular dermis, amniotic membrane, Wharton'"'"'s jelly, and combinations thereof, andwherein the first membrane and the one or more additional membranes of the tissue graft are not held in together with a suture.
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Accused Products
Abstract
Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
111 Citations
10 Claims
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1. A tissue graft comprising:
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a first membrane comprising modified amnion wherein the modified amnion has a first side which is an exposed basement membrane and a second side which is a fibroblast layer; and one or more additional membranes laminated to the first membrane, wherein the one or more additional membranes is selected from the group consisting of amnion, chorion, allograft pericardium, allograft acellular dermis, amniotic membrane, Wharton'"'"'s jelly, and combinations thereof, and wherein the first membrane and the one or more additional membranes of the tissue graft are not held in together with a suture. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification