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Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders

  • US 9,084,876 B2
  • Filed: 03/15/2013
  • Issued: 07/21/2015
  • Est. Priority Date: 08/04/2004
  • Status: Active Grant
First Claim
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1. A method for delivering a substance to a location within a paranasal sinus or nasal cavity, or an opening into a paranasal sinus or nasal cavity of a human or animal subject to treat a disorder, said method comprising the steps of:

  • obtaining or providing a device that comprises;

    a self-expanding structure comprising a plurality of interconnected elongate members which comprise biodegradable material combined with a therapeutic substance, wherein said self-expanding structure is resiliently biased to assume a radially expanded configuration, such that said self-expanding structure is initially constrainable in a radially collapsed configuration from which it will self-expand to the radially expanded configuration when unconstrained; and

    an introducer device comprising a tube having a distal end opening and a lumen and a pusher, said self-expanding structure being loaded in the collapsed configuration within said lumen distal to said pusher, wherein the tube is configured to hold the self-expanding structure in the collapsed configuration, against a resilient bias of the self-expanding structure, while the self-expanding structure is loaded into the tube;

    inserting the introducer device into the nose to a position where its distal end opening is aligned with the paranasal sinus or nasal cavity or the opening into the paranasal sinus or the opening into the nasal cavity;

    causing the pusher to advance, thereby delivering the self-expanding structure out of the distal end opening of the introducer device so that the self-expanding structure self-expands within the paranasal sinus or nasal cavity or the opening into the paranasal sinus or the opening into the nasal cavity; and

    leaving the self-expanding structure in place for a period of time over which the biodegradable material degrades and wherein the therapeutic substance is released.

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