×

Ophthalmic drug delivery

  • US 9,087,145 B2
  • Filed: 07/15/2011
  • Issued: 07/21/2015
  • Est. Priority Date: 07/15/2010
  • Status: Active Grant
First Claim
Patent Images

1. A method of delivering a medicament to an eye of a subject in need thereof as an ejected stream of droplets, the method comprising:

  • (a) generating the ejected stream of droplets containing said medicament via a piezoelectric actuated ejection device, said ejector device comprising;

    a housing;

    a reservoir disposed within the housing for receiving a volume of ophthalmic fluid;

    an ejector mechanism comprising an ejector plate having a first surface coupled to a fluid delivery area of the reservoir, the ejector plate including a plurality of openings formed through its thickness; and

    a piezo electric actuator coupled to a second surface of the ejector plate, the actuator being operable to oscillate the ejector plate at a frequency to thereby generate the ejected stream of droplets upon actuation;

    wherein said ejected droplets have an average droplet ejecting size of between about 20 microns to about 100 microns in diameter and an average initial droplet ejecting velocity between 1 m/s and 10 m/s; and

    (b) delivering said ejected stream of droplets containing said medicament to said eye of the subject in need thereof, wherein between about 85% to about 100% of the ejected mass of said droplets are deposited on the eye.

View all claims
  • 5 Assignments
Timeline View
Assignment View
    ×
    ×