Calibration of glucose monitoring sensor and/or insulin delivery system
First Claim
Patent Images
1. A method comprising:
- obtaining, from a blood-glucose sensor, one or more blood glucose sensor measurements;
obtaining one or more reference sample signals based at least in part on one or more blood glucose reference samples;
combining, via a processor, said one or more reference sample signals and said one or more blood glucose measurements to provide a plurality of blood glucose reference sample-sensor measurement pairs;
estimating one or more parameters of a plurality of probability models based, at least in part, on said blood glucose reference sample-sensor measurement pairs;
determining a plurality of functions for estimating a blood-glucose concentration in a patient from sensor measurements based, at least in part, on said estimated one or more parameters of said plurality of probability models;
for each of said plurality of functions, estimating a sensor glucose concentration value by application of said function to provide a plurality of estimated sensor glucose concentration values, each of said estimated sensor glucose concentration values being generated by a corresponding one of said plurality of functions; and
determining a composite sensor glucose concentration value for the patient based, at least partly, on a combination of said plurality of estimated sensor glucose concentration values.
1 Assignment
0 Petitions
Accused Products
Abstract
Disclosed are methods, apparatuses, etc. for calibrating glucose monitoring sensors and/or insulin delivery systems. In certain example embodiments, blood glucose reference samples may be correlated with sensor measurements with regard to a delay associated with the sensor measurements. In certain other example embodiments, one or more parameters of a probability model may be estimated based on blood glucose reference sample-sensor measurement pairs. Based on such information, function(s) for estimating a blood-glucose concentration in a patient may be determined.
-
Citations
27 Claims
-
1. A method comprising:
-
obtaining, from a blood-glucose sensor, one or more blood glucose sensor measurements; obtaining one or more reference sample signals based at least in part on one or more blood glucose reference samples; combining, via a processor, said one or more reference sample signals and said one or more blood glucose measurements to provide a plurality of blood glucose reference sample-sensor measurement pairs; estimating one or more parameters of a plurality of probability models based, at least in part, on said blood glucose reference sample-sensor measurement pairs; determining a plurality of functions for estimating a blood-glucose concentration in a patient from sensor measurements based, at least in part, on said estimated one or more parameters of said plurality of probability models; for each of said plurality of functions, estimating a sensor glucose concentration value by application of said function to provide a plurality of estimated sensor glucose concentration values, each of said estimated sensor glucose concentration values being generated by a corresponding one of said plurality of functions; and determining a composite sensor glucose concentration value for the patient based, at least partly, on a combination of said plurality of estimated sensor glucose concentration values. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
-
14. An apparatus comprising:
-
a calibration unit to receive one or more signals based on blood-glucose sensor measurements, said calibration unit comprising one or more processors programmed to; obtain a plurality of blood glucose reference sample-sensor measurement pairs; estimate one or more parameters of a plurality of probability models based, at least in part, on said blood glucose reference sample-sensor measurement pairs; determine a plurality of functions for estimating a blood-glucose concentration in a patient from sensor measurements based, at least in part, on said estimated one or more parameters of said plurality of probability models; for each of said plurality of functions, estimate a sensor glucose concentration value by application of said function to provide a plurality of estimated sensor glucose concentration values, each of said estimated sensor glucose concentration values being generated by a corresponding one of said plurality of functions; and determine a composite sensor glucose concentration value for the patient based, at least in part, on a combination of said plurality of estimated sensor glucose concentration values. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
-
-
26. A system comprising:
-
means for obtaining a plurality of blood glucose reference sample-sensor measurement pairs; means for estimating one or more parameters of a plurality of probability models based, at least in part, on said blood glucose reference sample-sensor measurement pairs; means for determining a plurality of functions for estimating a blood-glucose concentration in a patient from sensor measurements based, at least in part, on said estimated one or more parameters of said plurality of probability models; for each of said plurality of functions, means for estimating a sensor glucose concentration value by application of said function to provide a plurality of estimated sensor glucose concentration values, each of said estimated sensor glucose concentration values being generated by a corresponding one of said plurality of functions; and means for determining a composite sensor glucose concentration value for the patient based, at least partly, on a combination of said plurality of estimated sensor glucose concentration values.
-
-
27. An article comprising:
-
at least one non-transitory storage medium having stored thereon instructions executable by one or more processors to; obtain a plurality of blood glucose reference sample-sensor measurement pairs; estimate one or more parameters of a plurality of probability models based, at least in part, on said blood glucose reference sample-sensor measurement pairs; determine a plurality of functions for estimating a blood-glucose concentration in a patient from sensor measurements based, at least in part, on said estimated one or more parameters of said plurality of probability models; for each of said plurality functions estimate a sensor glucose concentration value by application of said function to provide a plurality of estimated sensor glucose concentration values, each of said estimated sensor glucose concentration values being generated by a corresponding one of said plurality of functions; and determine a composite sensor glucose concentration value for the patient based, at least part, on a combination of said plurality of estimated sensor glucose concentration values.
-
Specification