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Drug delivery devices and methods

  • US 9,089,392 B2
  • Filed: 08/23/2013
  • Issued: 07/28/2015
  • Est. Priority Date: 12/23/2009
  • Status: Active Grant
First Claim
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1. A method of implanting an ocular implant for treating an ocular disorder of an eye, comprising:

  • forming a self-sealing incision in the cornea of the eye into the anterior chamber of the eye;

    introducing an implant through the incision into the anterior chamber, the implant comprising;

    a proximal end with at least one inflow port;

    a distal end with at least one outflow port; and

    an internal lumen extending through the implant between the at least one inflow port and at least one outflow port,wherein the implant is mounted on an implantation instrument having a delivery wire extending through the internal lumen of the implant;

    positioning the implant in the eye using the implantation instrument and the delivery wire on which the implant is mounted, wherein the implant is positioned between a first and second tissue layer and into fluid communication with the suprachoroidal space using the delivery wire on which the implant is mounted;

    withdrawing the delivery wire from the internal lumen of the implant;

    injecting drug-release material through the delivery wire as the delivery wire is being withdrawn from the internal lumen of the implant filling the internal lumen of the implant with the drug-release material, wherein injecting drug-release material includes creating a lake of the drug-release material near the distal end of the implant;

    eluting the at least one active agent from the drug-release material to treat the eye as the drug-release material degrades, wherein the space is maintained after the lake of drug-release material degrades.

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