×

Formulation of indomethacin

  • US 9,089,471 B2
  • Filed: 05/22/2014
  • Issued: 07/28/2015
  • Est. Priority Date: 04/24/2009
  • Status: Active Grant
First Claim
Patent Images

1. A method of treating pain comprising administering a solid unit dose of a pharmaceutical composition containing 20 mg of indomethacin wherein the unit dose when tested in vitro by USP Apparatus I (Basket) method of U.S. Pharmacopoeia at 100 rpm at 37°

  • C. in 900 ml of 100 mM citric acid buffer (pH 5.5±

    0.05) has a dissolution rate of indomethacin such that at least 83%, by weight, is released by 75 minutes and wherein the D90 of the indomethacin, on a particle volume basis, is selected from the group consisting of;

    less than 5000 nm, less than 4000 nm, 3000 nm, less than 2000 nm, less than 1900 nm, less than 1800 nm, and less than 1700 nm.

View all claims
  • 3 Assignments
Timeline View
Assignment View
    ×
    ×