Administration apparatus, operating method thereof and administration method

• US 9,089,644 B2
• Filed: 09/08/2011
• Issued: 07/28/2015
• Est. Priority Date: 09/14/2010
• Status: Expired due to Fees

• Current Assignee: Ricoh Company Limited, Yuki Kitaoka
• Original Assignee: Ricoh Company Limited, Yuki Kitaoka
• Inventors: Kitaoka, Yuki, Kameyama, Kenji, Nishimiya, Masanobu
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): LEE, WENG WAH
• Application Number:
  US13/822,054
• Publication Number:
  US 20130165906A1
• Time in Patent Office: 1,419 Days
• Field of Search: 604/506, 604/500, 604/890.1
• US Class Current: 1/1
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients

Abstract

An administration apparatus to administer an inhibitor drug to a patient to inhibit cell division of a malignant cell includes an administration unit configured to administer the inhibitor drug to the patient; an administration timing storage unit configured to store an administration time to start an administration of the inhibitor drug; a time measurement unit configured to measure a current time; and a control unit configured to drive and control the administration unit so as to administer the inhibitor drug to the patient when the current time coincides with the administration time. The administration time is set on a basis of a predetermined phase of a cell cycle of the malignant cell.

Claims

1. An administration apparatus to administer an inhibitor drug to a patient to inhibit cell division of a malignant cell comprising:

an administration unit configured to administer the inhibitor drug to the patient;

an administration timing storage unit configured to store an administration time to start an administration of the inhibitor drug;

a time measurement unit configured to measure a current time; and

a control unit configured to drive and control the administration unit so as to administer the inhibitor drug to the patient when the current time coincides with the administration time,

wherein the administration time is set on a basis of a predetermined phase of a cell cycle of the malignant cell,

a phase when a cell division inhibition effect by the inhibitor drug is the highest is selected as the predetermined phase in the cell cycle;

the cell cycle is divided into a plurality of groups by a predetermined period not more than a duration time of the predetermined phase; and

the administration time is intermittently set plural times at not less than (T+t) intervals if the cell cycle is a duration time T, and the predetermined period is a duration time t, and is set so that a difference of respective sequential administration times for the plurality of groups is less than a two cycle period.

2. The administration apparatus as claimed in claim 1,

wherein the predetermined period is set at the duration time of the predetermined phase.

3. The administration apparatus as claimed in claim 2, further comprising:

an administration period storage unit to store an administration period to administer the inhibitor drug continuously,

wherein the administration period is set at not more than the duration time of the predetermined phase.

4. The administration apparatus as claimed in claim 3,

wherein the administration time is set so that intervals before and after the administration time equal (AT+t) if A is made a constant of a natural number.

5. The administration apparatus as claimed in claim 3, further comprising:

an administration rate storage unit to store an administration rate to administer the inhibitor drug; and

a medication information input unit to allow medication information to be input,

wherein a dosage is input and set through the medication information input unit, and a continuous combination of administration and non-administration of the inhibitor drug is made a basic cycle based on the dosage, the administration time, the administration period, and the administration rate; and

wherein a whole control including a number of the units needed to administer the dosage to the patient, and the control unit perform the whole control automatically.

6. The administration apparatus as claimed in claim 1,

wherein the administration time is set at a number not less than the number of the plural groups.

7. The administration apparatus as claimed in claim 1,

wherein the malignant cell is a cancer cell;

and

the inhibitor drug is a anticancer drug.

8. The administration apparatus as claimed in claim 1,

wherein the inhibitor drug is a drug solution;

and

the administration unit administers the drug solution by transfusion to a blood circulating system in the patient'"'"'s body.

9. The administration apparatus as claimed in claim 8,

wherein the administration unit includes a transfusion pump.

10. The administration apparatus as claimed in claim 8,

wherein the administration unit includes a blocking unit to block a channel for the transfusion during the non-administration.

11. The administration apparatus as claimed in claim 10,

wherein the administration unit includes a flow sensor in the channel for the transfusion, and

the control unit performs a feedback control so as to make a flow rate of the drug solution constant, based on a flow rate value detected by the flow rate sensor.

12. The administration apparatus as claimed in claim 11, further comprising:

a blocking warning unit to warn that the channel for the drug solution is blocked,

wherein the control unit blocks the channel for the drug solution by the blocking unit, and warns that the channel for the drug solution is blocked by driving the blocking warning unit if the flow rate value detected by the flow rate sensor is over a predetermined standard value.

13. An operating method of an administration apparatus, the administration apparatus including,

an administration unit configured to administer an inhibitor drug to a patient to inhibit cell division of a malignant cell;

an administration timing storage unit configured to store an administration time at which to start an administration of the inhibitor drug;

a time measurement unit configured to measure a current time;

an administration period storage unit to store an administration period of administering the inhibitor drug continuously to the patient; and

a control unit configured to drive and control the administration unit so as to administer the inhibitor drug to the patient when the current time coincides with the administration time,

the operating method comprising the steps of;

setting the administration time and the administration period on a basis of a predetermined phase of the cell cycle of the malignant cell;

storing the set administration time in the administration time storage unit and the set administration period in the administration period storage unit respectively; and

administering the inhibitor drug to the patient continuously for the administration period when the current time measured by the time measurement unit coincides with the administration time by controlling the administration unit with the control unit,

wherein a phase when a cell division inhibition effect by the inhibitor drug is the highest is selected as the predetermined phase in the cell cycle;

the cell cycle is divided into a plurality of groups by a predetermined period not more than a duration time of the predetermined phase; and

the administration time is intermittently set plural times at not less than (T+t) intervals if the cell cycle is a duration time T, and the predetermined period is a duration time t, and is set so that a difference of respective sequential administration times for the plurality of groups is less than a two cycle period.

14. An administration method to administer an inhibitor drug to a patient to inhibit cell division of a malignant cell, comprising the steps of:

setting an administration time to start an administration of the inhibitor drug to the patient on a basis of a predetermined phase of the cell cycle division of the malignant cell;

storing the set administration time in an administration time storage unit; and

administering the inhibitor drug to the patient continuously when the current time coincides with the administration time stored in the administration storage unit,

wherein a phase when a cell division inhibition effect by the inhibitor drug is the highest is selected as the predetermined phase in the cell cycle;

the cell cycle is divided into a plurality of groups by a predetermined period not more than a duration time of the predetermined phase; and

the administration time is intermittently set plural times at not less than (T+t) intervals if the cell cycle is a duration time T, and the predetermined period is a duration time t, and is set so that a difference of respective sequential administration times for the plurality of groups is less than a two cycle period.