Systems, methods and devices for paired plasticity
First Claim
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1. A method of training for treating a motor deficit resulting from stroke in a patient, comprising:
- assessing a patient'"'"'s motor deficit caused by a stroke;
selecting a skilled motor task based on the patient'"'"'s motor deficit;
providing a repeated paired training therapy by repeatedly performing the selected skilled motor task, wherein each performance of the selected skilled motor task is paired with a vagus nerve stimulation pulse train by presenting the vagus nerve stimulation pulse train during the performance of the selected motor task, and not presenting a vagus nerve stimulation pulse train between performances of the selected skilled motor task, wherein the vagus nerve stimulation pulse train is generated by a subcutaneous device that provides electrical stimulation to the patient'"'"'s vagus nerve;
repeatedly performing the paired skilled motor task; and
reducing the patient'"'"'s motor deficit,wherein the method further comprises the action of sensing respective beginnings of the performances of the selected skilled motor tasks, and applying the respective vagus nerve stimulation pulse trains based on the sensed beginnings of the performances, and wherein the paired vagus nerve stimulation pulse trains end before the end of the respective skilled motor tasks.
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Abstract
Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.
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Citations
32 Claims
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1. A method of training for treating a motor deficit resulting from stroke in a patient, comprising:
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assessing a patient'"'"'s motor deficit caused by a stroke; selecting a skilled motor task based on the patient'"'"'s motor deficit; providing a repeated paired training therapy by repeatedly performing the selected skilled motor task, wherein each performance of the selected skilled motor task is paired with a vagus nerve stimulation pulse train by presenting the vagus nerve stimulation pulse train during the performance of the selected motor task, and not presenting a vagus nerve stimulation pulse train between performances of the selected skilled motor task, wherein the vagus nerve stimulation pulse train is generated by a subcutaneous device that provides electrical stimulation to the patient'"'"'s vagus nerve; repeatedly performing the paired skilled motor task; and reducing the patient'"'"'s motor deficit, wherein the method further comprises the action of sensing respective beginnings of the performances of the selected skilled motor tasks, and applying the respective vagus nerve stimulation pulse trains based on the sensed beginnings of the performances, and wherein the paired vagus nerve stimulation pulse trains end before the end of the respective skilled motor tasks. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of training for treating a motor deficit resulting from an event experienced by a patient, comprising:
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repeatedly performing a selected skilled motor task and sensing respective beginnings of the performances of the selected skilled motor task, wherein at least some of the repeated performances of the selected skilled motor task are accompanied by a simultaneous vagus nerve stimulation pulse train based on the sensed beginnings of the performances, wherein the accompanied vagus nerve stimulation pulse trains end before the end of the respective skilled motor tasks; and
wherein the vagus nerve stimulation pulse train is generated by a device that provides electrical stimulation to the patient'"'"'s vagus nerve; andreducing the patient'"'"'s motor deficit due to the repeated performance of the selected skilled motor task in association with the respective vagus nerve stimulation. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A method of training for treating a motor deficit resulting from an event experienced by a patient, comprising:
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repeatedly performing a selected skilled motor task and sensing respective beginnings of the performances of the selected skilled motor task, wherein at least some of the repeated performances of the selected skilled motor task are paired with a vagus nerve stimulation pulse train based on the sensed beginnings of the performances, wherein the paired vagus nerve stimulation pulse trains end before the end of the respective skilled motor tasks; and
, wherein the vagus nerve stimulation pulse train is generated by a device that provides electrical stimulation to the patient'"'"'s vagus nervereducing the patient'"'"'s motor deficit due to the repeated performance of the selected skilled motor task in association with the respective vagus nerve stimulation. - View Dependent Claims (16, 17, 18, 19, 20)
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21. A method of training for treating a motor deficit resulting from an event experienced by a patient, comprising:
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repeatedly performing a selected skilled motor task and sensing respective beginnings of the performances of the selected skilled motor task, wherein all of the repeated performances of the selected skilled motor task are paired with a vagus nerve stimulation pulse train, wherein the paired vagus nerve stimulation pulse trains do not begin prior to the beginning of the skilled motor task and end before the end of the skilled motor task; and
wherein the vagus nerve stimulation pulse train is generated by a device that provides electrical stimulation to the patient'"'"'s vagus nerve; andreducing the patient'"'"'s motor deficit due to the repeated performance of the selected skilled motor task in association with the respective vagus nerve stimulation. - View Dependent Claims (22, 23, 24)
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25. A method of training for treating a motor deficit resulting from an event experienced by a patient, comprising:
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assessing a patient'"'"'s motor deficit caused by the event; selecting a skilled motor task based on the patient'"'"'s motor deficit; repeatedly performing the selected skilled motor task and sensing respective beginnings of the performances of the selected skilled motor task, wherein the repeated performances of the selected skilled motor task is paired with a vagus nerve stimulation pulse train by presenting the vagus nerve stimulation pulse train during the performance of the selected motor task based on the sensed beginnings of the performances, wherein the paired vagus nerve stimulation pulse trains end before the end of the respective skilled motor tasks; and
wherein the vagus nerve stimulation pulse train is generated by a device that provides electrical stimulation to the patient'"'"'s vagus nerve; andreducing the patient'"'"'s motor deficit due to the repeated performance of the selected skilled motor task paired with the vagus nerve stimulation. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32)
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Specification