Non-invasive methods and devices for inducing euphoria in a patient and their therapeutic application

• US 9,089,719 B2
• Filed: 02/10/2011
• Issued: 07/28/2015
• Est. Priority Date: 03/20/2009
• Status: Active Grant

• Current Assignee: electroCore, Inc.
• Original Assignee: Electrocore, Llc
• Inventors: Simon, Bruce J., Errico, Joseph P., Raffle, John T.
• Primary Examiner(s): VOORHEES, CATHERINE M
• Application Number:
  US13/024,727
• Publication Number:
  US 20110190569A1
• Time in Patent Office: 1,629 Days
• Field of Search: 607/2, 607 45- 46, 607/72, 607/75, 607/103, 600/9, 600 13- 15
• US Class Current: 1/1
• CPC Class Codes: A61M 2021/0055 with electric or electro-magnetic fields
• CPC Class Codes: A61M 21/02 for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021
• CPC Class Codes: A61N 1/18 Applying electric currents by contact electrodes
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals

Abstract

A novel non-invasive magnetic stimulator is used to modulate electrical activity of a patient'"'"'s vagus nerve. Parameters of the stimulation are selected in such a way as to induce a state of euphoria in the patient. The methods and devices may be used for anesthesia, or to treat insomnia, depression, or premenstrual syndromes. They may be used as substitution withdrawal tools for individuals who otherwise would depend on substances and behaviors to achieve a euphoric state of mind, particularly individuals who abusively consume drugs, alcohol or food, or who exhibit behavioral disorders such as compulsive gambling. The devices and methods may also be used to prevent, manage, or relieve stress.

Claims

1. A method for modulating a state of mind of a patient, the method comprising:

positioning a device in contact with an outer skin surface of a neck of the patient; and

applying, via the device, energy transcutaneously and non-invasively through the outer skin surface of the neck of the patient to generate an electrical impulse at or near a vagus nerve within the patient, wherein the electrical impulse is sufficient to induce euphoria in the patient.

2. The method of claim 1, wherein the applying is carried out by generating a magnetic field exterior to the patient, wherein the magnetic field is sufficient to induce an electrical impulse at or near the vagus nerve within the patient.

3. The method of claim 1, wherein the electrical impulse is sufficient to stimulate nerve fibers that control or mediate an induction of the euphoria in the patient.

4. The method of claim 1 wherein the energy is applied to target a right branch of the vagus nerve.

5. The method of claim 1 wherein the energy is applied to target a left branch of the vagus nerve.

6. The method of claim 1, wherein a left branch and a right branch of the vagus nerve are stimulated simultaneously via the applying.

7. The method of claim 1, wherein the applying is carried out by:

generating a time-varying magnetic field that is located essentially entirely outside of the patient;

shaping an electric field that is induced by said magnetic field; and

conducting an electric current that is induced by said magnetic field through the outer skin surface of the neck of the patient to modulate the vagus nerve.

8. The method of claim 1 wherein the vagus nerve is at least approximately 1-2 cm below an outer skin surface of the patient.

9. The method of claim 8, further comprising:

substantially constraining, via the device, an electric current from modulating one or more nerves in a region between the outer skin surface and the vagus nerve.

10. The method of claim 7 wherein the generating comprises generating the time-varying magnetic field within an enclosed coil.

11. The method of claim 10, wherein the enclosed coil is a first enclosed coil, wherein the shaping comprises generating a second time-varying magnetic field within a second enclosed coil positioned near or adjacent to the first enclosed coil.

12. The method of claim 10, wherein the shaping comprises positioning a conducting medium around a portion of the enclosed coil such that a direction of the electrical field is constrained within the conducting medium.

13. The method of claim 7, wherein the conducting is carried out by electrically coupling the induced electric field to a target region within the patient allowing current to flow through the outer skin surface of the neck of the patient.

14. The method of claim 1, wherein the electrical impulse is sufficient to cause dopaminergic neurons originating in a ventral tegmental area of a brain of the patient to stimulate neurons or tissue to which said dopaminergic neurons project.

15. The method of claim 14 wherein the stimulation by dopaminergic neurons is modulated by endogenous opioids and cannabinoids.

16. The method of claim 1 wherein the patient is in need of dissociative anesthesia.

17. The method of claim 1 wherein the patient is in need of sleep.

18. The method of claim 1 wherein the patient is depressed.

19. The method of claim 1 wherein the patient abuses drugs or alcohol and wherein the induced euphoria substitutes for consumption of said drugs or alcohol.

20. The method of claim 1 wherein the patient has an eating disorder and wherein the induced euphoria terminates an eating binge.

21. The method of claim 1 wherein the patient has bulimia nervosa and wherein the induced euphoria is used to cause the patient to eat.

22. The method of claim 1 wherein the induced euphoria is used to prevent or relieve psychosocial stress.

23. The method of claim 1 wherein the patient compulsively gambles or shops and wherein the induced euphoria substitutes for said compulsive gambling or shopping.

24. The method of claim 1, wherein the electrical impulse is based at least in part on an electric field with an amplitude of greater than about 10 V/m.

25. The method of claim 1, wherein the electrical impulse is based at least in part on an electric field with a gradient of greater than about 2 V/m/mm.

26. The method of claim 1, wherein the electrical impulse comprises bursts of pulses with a frequency from about 5 Hz to about 100 Hz.

27. The method of claim 1, wherein the electrical impulse comprises bursts from about 1 pulse to about 20 pulses with each of the pulses from about 50 microseconds to about 1000 microseconds in duration.