Antibodies that specifically bind to A beta oligomers and use thereof
First Claim
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1. An antibody that recognizes an isolated A beta (Aβ
- ) tetramer as an antigen, wherein the antibody does not bind to an Aβ
monomer, and wherein the antibody comprises a heavy chain having CDR1, CDR2, and CDR3, which are identified in heavy chain variable region comprising the amino acid sequence of SEQ ID NO;
594, and a light chain having CDR1, CDR2, and CDR3, which are identified in light chain variable region comprising the amino acid sequence of SEQ ID NO;
596.
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Abstract
The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer'"'"'s disease.
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Citations
13 Claims
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1. An antibody that recognizes an isolated A beta (Aβ
- ) tetramer as an antigen, wherein the antibody does not bind to an Aβ
monomer, and wherein the antibody comprises a heavy chain having CDR1, CDR2, and CDR3, which are identified in heavy chain variable region comprising the amino acid sequence of SEQ ID NO;
594, and a light chain having CDR1, CDR2, and CDR3, which are identified in light chain variable region comprising the amino acid sequence of SEQ ID NO;
596. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- ) tetramer as an antigen, wherein the antibody does not bind to an Aβ
Specification