Sample measurement device, sample measurement system and sample measurement method

• US 9,091,641 B2
• Filed: 12/17/2012
• Issued: 07/28/2015
• Est. Priority Date: 03/27/2008
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Healthcare Holdings Co., Ltd.
• Inventors: Nakamura, Toshifumi, Shinno, Teppei
• Primary Examiner(s): Baldridge, Benjamin M
• Application Number:
  US13/716,514
• Publication Number:
  US 20130105334A1
• Time in Patent Office: 953 Days
• Field of Search: 324/532, 205/777, 205/777.5, 600/365
• US Class Current: 1/1
• CPC Class Codes: G01N 27/327 Biochemical electrodes , e.g. electrical or mechanical details for in vitro measurements
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771

Abstract

A sample measurement device (110), in which a biosensor (30) having an electrode is mounted, voltage is applied to the electrode, and the concentration of a specific component in a sample deposited on the biosensor (30) is measured, comprises a voltage source (19) configured to apply voltage to the electrode, a time measurement component (22), and a controller (18) configured to control the voltage to be applied and measure the concentration of the specific component. The time measurement component (22) measures a detection time, which is the length of time between the mounting of the biosensor (30) and the deposition of a sample on the biosensor (30). The controller (18) changes a set value for measuring the concentration of a specific component according to the detection time. Consequently, measurement accuracy can be improved regardless of the temperature of the biosensor (30).

Claims

1. A sample measurement device for measuring a concentration of a specific component included in a sample deposited on a biosensor, which is attachable to the sample measurement device, the sample measurement device comprising:

a voltage source that applies voltage to an electrode of the biosensor;

a time measurement component that measures a detection time, the detection time being a length of time from when the biosensor is attached to the sample measurement device until when the sample is deposited on the biosensor; and

a controller that (i) controls the voltage applied by the voltage source, (ii) detects the sample deposited on the biosensor, (iii) measures the concentration of the specific component included in the sample, and (iv) sets a time from when the sample deposited on the biosensor is detected until when the voltage is applied to the electrode of the biosensor, according to the detection time detected by the time measurement component.

2. The sample measurement device according to claim 1,

wherein a value of the voltage applied to the electrode of the biosensor is a value of voltage for measuring the concentration of the specific component included in the sample.

3. The sample measurement device according to claim 2,

wherein the shorter is the detection time, the more the controller extends the time from when the sample deposited on the biosensor is detected until when the voltage is applied to the electrode of the biosensor.

4. The sample measurement device according to claim 1,

wherein the controller:

determines whether or not the detection time is within a specified length of time; and

when determining that the detection time is within the specified length of time, changes the time from when the sample deposited on the biosensor is detected until when the voltage is applied to the electrode of the biosensor.

5. The sample measurement device according to claim 1,

further comprising a temperature measurement component configured to measure an environment temperature,

wherein the controller further changes the time from when the sample deposited on the biosensor is detected until when the voltage is applied to the electrode of the biosensor, according to the environment temperature measured by the temperature measurement component.

6. The sample measurement device according to claim 1,

further comprising a hematocrit value calculation unit,

wherein the controller further changes the time from when the sample deposited on the biosensor is detected until when the voltage is applied to the electrode of the biosensor, according to the hematocrit value calculated by the hematocrit value calculation unit.

7. The sample measurement device according to claim 1,

wherein the controller changes a value of the voltage applied to the electrode of the biosensor, according to the detection time.

8. The sample measurement device according to claim 1,

wherein the controller sets the time from when the sample deposited on the biosensor is detected until when the voltage is applied to the electrode of the biosensor, according to a type of the sample.

9. The sample measurement device according to claim 1,

wherein the specific component included in the sample includes a plurality of types of specific components, and

the controller changes the time from when the sample deposited on the biosensor is detected until when the voltage is applied to the electrode of the biosensor, for each of the specific components.

10. A sample measurement system, comprising:

the sample measurement device according to claim 1; and

a biosensor that is attachable to the sample measurement device.

11. The sample measurement system according to claim 10,

wherein the sample measurement system comprises a plurality of biosensors, and

the sample measurement device measures the concentrations of a plurality of types of specific components.

12. The sample measurement system according to claim 11,

wherein the sample measurement system comprises a plurality of biosensors, and

the sample measurement device measures the concentration of one type of specific component.

13. A sample measurement method using a sample measurement device including a voltage source that applies voltage to an electrode of a biosensor, which is attachable to the sample measurement device, the sample measurement device measuring a concentration of a specific component included in a sample deposited on the biosensor, said sample measurement method comprising:

measuring a detection time, the detection time being a length of time from when the biosensor is attached to the sample measurement device until when the sample is deposited on the biosensor;

changing a set value for measuring the concentration of the specific component included in the sample, according to the detection time; and

setting a time from when the sample deposited on a biosensor is detected until when the voltage is applied to the electrode of the biosensor, on the basis of the set value.

14. The sample measurement method according to claim 13,

wherein a value of the voltage applied to the electrode of the biosensor is a value of voltage for measuring the concentration of the specific component included in the sample.

15. The sample measurement method according to claim 14,

wherein, in said changing the set value, the shorter is the detection time, the more the time from when the sample deposited on the biosensor is detected until when the voltage is applied to the electrode of the biosensor is extended.

16. The sample measurement method according to claim 13,

wherein said changing the set value further includes:

determining whether or not the detection time is within a specified length of time, and

when determining that the detection time is within the specified length of time, changing the time from when the sample deposited on the biosensor is detected until when the voltage is applied to the electrode of the biosensor.

17. The sample measurement method according to claim 13,

further comprising measuring an environment temperature,

wherein said changing the set value further includes changing the time from when the sample deposited on the biosensor is detected until when the voltage is applied to the electrode of the biosensor, according to the environment temperature measured in said measuring the environment temperature.

18. The sample measurement method according to claim 13,

further comprising calculating a hematocrit value,

wherein said changing the set value further includes changing the time from when the sample deposited on the biosensor is detected until when the voltage is applied to the electrode of the biosensor, according to the hematocrit value calculated in said calculating the hematocrit value.

19. The sample measurement method according to claim 13,

further comprising changing a value of the voltage applied to the electrode of the biosensor, according to the detection time.

20. The sample measurement method according to claim 13,

further comprising setting the time from when the sample deposited on a biosensor is detected until when the voltage is applied to the electrode of the biosensor, according to a type of the sample.