Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
First Claim
Patent Images
1. An apparatus comprising:
- a dessicated, amorphous, translucent, flexible, hydrogel film including;
a first film layer comprising uncrosslinked hyaluronic acid and alginate that is negatively charged and crosslinked with at least one calcium cation; and
a second film layer comprising uncrosslinked hyaluronic acid and alginate that is negatively charged and crosslinked with at least one calcium cation;
wherein (a) the first film layer is fused to the second film layer; and
(b) the first film layer is anti-adhesive and non-attractive to cells and the second film layer is adhesive to cells.
4 Assignments
0 Petitions
Accused Products
Abstract
A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.
-
Citations
11 Claims
-
1. An apparatus comprising:
-
a dessicated, amorphous, translucent, flexible, hydrogel film including; a first film layer comprising uncrosslinked hyaluronic acid and alginate that is negatively charged and crosslinked with at least one calcium cation; and a second film layer comprising uncrosslinked hyaluronic acid and alginate that is negatively charged and crosslinked with at least one calcium cation; wherein (a) the first film layer is fused to the second film layer; and
(b) the first film layer is anti-adhesive and non-attractive to cells and the second film layer is adhesive to cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
Specification