Magnetic nanostructures as theranostic agents

• US 9,095,629 B2
• Filed: 11/01/2010
• Issued: 08/04/2015
• Est. Priority Date: 10/30/2009
• Status: Active Grant

• Current Assignee: Northwestern University
• Original Assignee: Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University
• Inventors: Dravid, Vinayak P., Sharma, Saurabh, Tomita, Tadanori, Viola, Kirsten L., Klein, William L.
• Primary Examiner(s): Justice, Gina
• Application Number:
  US13/505,167
• Publication Number:
  US 20120308657A1
• Time in Patent Office: 1,737 Days
• Field of Search: 424/429
• US Class Current: 1/1
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61K 47/6865 the tumour determinant being from skin, nerves or brain cancer cell
• CPC Class Codes: A61K 47/6923 the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
• CPC Class Codes: A61K 49/1833 having a (super)(para)magnetic core coated or functionalised with a small organic molecule oligomeric, polymeric, dendrimeric A61K49/1851
• CPC Class Codes: A61K 49/186 the organic macromolecular compound being polyethyleneglycol [PEG]
• CPC Class Codes: A61K 49/1875 coated or functionalised with an antibody
• CPC Class Codes: A61N 2/004 specially adapted for a specific therapy
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (e.g., medulloblastoma) and Alzheimer'"'"'s disease and related diseases and conditions.

Claims

1. A system, comprising

a) a magnetic nanostructure comprising i) a nanoparticle;

and ii) a targeting agent, wherein said targeting agent targets said nanostructure to an Aβ

-oligomer; and

b) a device for generating a radio frequency, wherein said magnetic nanostructure generates heat when exposed to a radio frequency generated by said radio frequency generator.

2. The system of claim 1, wherein said targeting agent is an antibody.

3. The system of claim 1, wherein said magnetic nanostructure is coated with a non-magnetic coating.

4. The system of claim 1, wherein said magnetic nanostructure is present in a stable suspension.

5. A method, comprising

a) administering a magnetic nanostructure comprising i) a nanoparticle;

and ii) a targeting agent, wherein said targeting agent targets said nanostructure to an Aβ

-oligomer to a subject;

b) detecting the presence of said Aβ

-oligomer in said subject by identifying said magnetic nanostructure; and

c) destroying said Aβ

-oligomer by exposing said magnetic nanostructure to a radio frequency that causes said magnetic nanostructure to generate heat.

6. The method of claim 5, wherein said identifying said magnetic nanostructure comprises the use of magnetic resonance imaging.

7. The method of claim 5, wherein said targeting agent is an antibody.

8. The method of claim 5, wherein said magnetic nanostructure is coated with a non-magnetic coating.

9. The method of claim 5, wherein said magnetic nanostructure is present in a stable suspension.

10. A method, comprising

a) administering a magnetic nanostructure comprising i) a nanoparticle;

and ii) a targeting agent, wherein said targeting agent targets said nanostructure to an Aβ

-oligomer to a subject; and

b) detecting the presence of said Aβ

-oligomer in said subject by identifying said magnetic nanostructure.

11. The method of claim 10, further comprising the step of destroying said Aβ

-oligomer by exposing said magnetic nanostructure to a radio frequency that causes said magnetic nanostructure to generate heat.

12. A method, comprising

a) administering a magnetic nanoparticle via injection to the site of an Aβ

-oligomer in a subject;

b) detecting the presence of said Aβ

-oligomer in said subject by identifying said magnetic nanoparticle; and

c) destroying said Aβ

-oligomer by exposing said magnetic nanoparticle to a radio frequency that causes said magnetic nanoparticle to generate heat.