Electrical stimulation method for modulation on sensory information around dorsal root ganglia

• US 9,095,712 B2
• Filed: 05/29/2013
• Issued: 08/04/2015
• Est. Priority Date: 05/29/2012
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Lee, Dongchul
• Primary Examiner(s): Holmes, Rex R
• Application Number:
  US13/904,891
• Publication Number:
  US 20130325084A1
• Time in Patent Office: 797 Days
• Field of Search: 607 1- 3, 607 46- 48, 607/59
• US Class Current: 1/1
• CPC Class Codes: A61N 1/36057 adapted for stimulating afferent nerves
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/37241 providing test stimulations
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

A method of treating a patient with an ailment, comprises delivering first energy to a dorsal root ganglia (DRG), thereby modulating the DRG, and delivering second energy to at least one of a central neural axon extending from the DRG and a peripheral neural axon extending from the DRG, thereby modulating the at least one of the central neural axon and the peripheral neural axon.

Claims

1. A method of treating a patient with an ailment, comprising:

providing an implanted neuromodulation lead comprising a plurality of electrodes, the plurality of electrodes comprising a first electrode and a second electrode spaced apart from the first electrode, wherein the first electrode is disposed over a dorsal root ganglia (DRG) and the second electrode is disposed over one of a central neural axon extending from the DRO or a peripheral neural axon extending from the DRG;

delivering first energy to the dorsal root ganglia using at least the first electrode but not the second electrode, thereby modulating the DRG; and

delivering second energy to the one of the central neural axon or the peripheral neural axon using at least the second electrode but not the first electrode, thereby modulating the one of the central neural axon or the peripheral neural axon, wherein the first energy and the second energy differ in at least one of frequency, energy type, pulse width, or pulse shape, wherein the first energy depolarizes or hyperpolarizes the DRG and the second energy blocks action potential initiation or changes an interpulse interval between action potentials in the one of the central neural axon or the peripheral neural axon.

2. The method of claim 1. wherein both the first energy and the second energy are electrical energy.

3. The method of claim 2, wherein the first electrical energy has a first frequency and the second electrical energy has a second frequency different from the first frequency.

4. The method of claim 3, wherein the first frequency is equal to or less than 500Hz, and the second frequency is greater than 500Hz.

5. The method of claim 1. wherein the second energy is delivered to one of the central neural axon or the peripheral neural axon, the method further comprising delivering third energy to the other of the central neural axon or the peripheral neural axon.

6. The method of claim 1 wherein the ailment is pain.

7. The method of claim 6, wherein the source of pain resides in the DRG and the second electrode is disposed over the central neural axon and the second energy is delivered to the central neural axon.

8. The method of claim 6, wherein the source of pain resides in the peripheral neural axon and the second electrode is disposed over the peripheral neural axon and the second energy is delivered to the peripheral neural axon.

9. The method of claim 6, wherein the source of pain resides both in the DRG and the peripheral neural axon and the second electrode is disposed over the peripheral neural axon and the second energy is delivered to the peripheral neural axon, the method further comprising delivering, third energy to the central neural axon.

10. The method of claim 5, wherein the neurostimulation lead comprises a third electrode, wherein the third electrode is disposed over the other one of the central neural axon or the peripheral neural axon, wherein the third energy is delivered using at least the third electrode but not the first and second electrodes.

11. The method of claim 10, wherein the third energy differs from both the first energy and the second energy in at least one of frequency, energy type, pulse width, or pulse shape.

12. A method of treating a patient with an ailment, comprising,:

providing an implanted neuromodulation lead comprising a plurality of electrodes, the plurality of electrodes comprising a first electrode and a second electrode spaced apart from the first electrode, wherein the first electrode is disposed over a dorsal root ganglia (DRG) and the second electrode is disposed over one of a central neural axon extending from the DRG or a peripheral neural axon extending from the DRG;

delivering first energy to the dorsal root ganglia using at least the first electrode but not the second electrode, thereby modulating the DRG; and

delivering second energy to the one of the central neural axon or the peripheral neural axon using at least the second electrode but not the first electrode, thereby modulating the one of the central neural axon or the peripheral neural axon, wherein the first energy and the second energy differ in at least one of frequency, energy type, pulse width, or pulse shape, wherein the first energy blocks action potential initiation or changes an interpulse interval between action potentials in the DRG and the second energy depolarizes or hyperpolarizes the one of the central neural axon or the peripheral neural axon.

13. The method of claim 12, wherein the first energy has a first frequency and the second energy has a second frequency different from the first frequency.

14. The method of claim 13, wherein the first frequency is greater than 500Hz, and the second frequency is equal to or less than 500Hz.

15. The method of claim 12, wherein the ailment is pain.

16. The method of claim 15, wherein the source of pain resides in the DRG and the second electrode is disposed over the central neural axon and the second energy is delivered to the central neural axon.

17. The method of claim 15, wherein the source of pain resides in the peripheral neural axon and the second electrode is disposed over the peripheral neural axon and the second energy is delivered to the peripheral neural axon.

18. The method of claim 15, wherein the source of pain resides both in the DRG and the peripheral neural axon and the second electrode is disposed over the peripheral neural axon and the second energy is delivered to the peripheral neural axon, the method further comprising delivering third energy to the central neural axon.

19. The method of claim 12, wherein the second energy is delivered to one of the central neural axon or the peripheral neural axon, the method further comprising delivering third energy to the other of the central neural axon or the peripheral neural axon.

20. The method of claim 19. wherein the neurostimulation lead comprises a third electrode, wherein the third electrode is disposed over the other one of the central neural axon or the peripheral neural axon, wherein the third energy is delivered using at least the third electrode but not the first and second electrodes, wherein the third energy differs from both the first energy and the second energy in at least one of frequency, energy type, pulse width, or pulse shape.