Heart-sounds based adaptive cardiac resynchronization therapy timing parameter optimization system

• US 9,095,718 B2
• Filed: 04/03/2013
• Issued: 08/04/2015
• Est. Priority Date: 04/04/2012
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Zhang, Xusheng, Gillberg, Jeffrey M, Mullen, Thomas J, Sambelashvili, Aleksandre T, DeGroot, Paul J
• Primary Examiner(s): Gedeon, Brian T
• Assistant Examiner(s): TEJANI, ANKIT D
• Application Number:
  US13/856,152
• Publication Number:
  US 20130268017A1
• Time in Patent Office: 853 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A medical device and associated method for controlling a cardiac pacing therapy sense a first cardiac signal including events corresponding to cardiac electrical events and a second cardiac signal including events corresponding to cardiac hemodynamic events. A processor is enabled to measure a cardiac conduction time interval using the first cardiac signal and control a signal generator to deliver a pacing therapy. A pacing control parameter is adjusted to a plurality of settings during the pacing therapy delivery. A hemodynamic parameter value is measured from the second cardiac signal during application of each of the control parameter settings. The processor identifies an optimal setting from the plurality of settings and solves for a patient-specific equation defining the pacing control parameter as a function of the cardiac conduction time interval.

Claims

1. A method, comprising:

sensing a first cardiac signal comprising first events corresponding to cardiac electrical events;

sensing a second cardiac signal comprising second events corresponding to cardiac hemodynamic events; and

enabling a processor to;

measure a cardiac conduction time interval using the first cardiac signal,

control a signal generator to deliver a pacing therapy and adjust a first pacing control parameter to a plurality of settings during the pacing therapy delivery,

measure a hemodynamic parameter value from the second cardiac signal corresponding to each of the plurality of settings,

identify an optimal setting from the plurality of settings in response to the measured hemodynamic parameter values,

use the identified optimal setting and the measured cardiac conduction time interval to solve for a first patient-specific equation configured to be used to adjust the first pacing control parameter based on cardiac conduction time interval, the first patient-specific equation defining the first pacing control parameter as a function of the cardiac conduction time interval, and

use the first patient-specific equation to compute a setting for the first pacing control parameter based on the cardiac conduction time interval.

2. The method of claim 1, wherein solving for the first patient-specific equation comprises computing a patient-specific value of at least one of a coefficient and an intercept.

3. The method of claim 1, further comprising enabling a processor to:

repeat measurement of the cardiac conduction time interval to obtain an updated conduction time interval; and

use the first patient-specific equation to compute an updated setting for the first pacing control parameter based on the updated cardiac conduction time interval.

4. The method of claim 1, further comprising enabling a processor to:

set a first time interval for updating the first patient-specific equation;

upon expiration of the first time interval, repeat measuring the hemodynamic parameter value from the second cardiac signal corresponding to each of the plurality of settings and identifying an updated optimal setting from the plurality of settings in response to the measured hemodynamic parameter values; and

use the identified updated optimal setting to solve for an updated first patient-specific equation.

5. The method of claim 4, further comprising enabling a processor to:

set a second time interval for updating the cardiac conduction time interval measurement, the second time interval different than the first time interval; and

upon expiration of the second time interval, repeat measurement of the cardiac conduction time interval to obtain an updated cardiac conduction time interval and use the updated first patient-specific equation to compute an updated setting for the first pacing control parameter based on the updated conduction time interval.

6. The method of claim 1, further comprising enabling the processor:

use an identified optimal setting of a second pacing control parameter identified in response to the second cardiac signal and the measured cardiac conduction time interval to solve for a second patient-specific equation configured to be used to adjust the second pacing control parameter based on cardiac conduction time interval, the second patient-specific equation defining the second pacing control parameter as a function of the cardiac conduction time interval;

control the signal generator to selectively deliver the pacing therapy in one of a first pacing mode and a second pacing mode in response to the first cardiac signal;

use the first patient-specific equation to compute an optimal setting for the first pacing control parameter in response to selectively delivering pacing according to the first pacing mode; and

use the second patient-specific equation to compute an optimal setting for the second pacing control parameter in response to selectively delivering pacing according to the second pacing mode.

7. The method of claim 6, wherein the first and second pacing modes comprise a single ventricle pacing mode and a biventricular pacing mode, respectively, the first pacing control parameter comprising an atrial-ventricular delay and the second pacing control parameter comprising a ventricular-ventricular delay.

8. The method of claim 1, wherein the hemodynamic signal comprises a heart sound signal.

9. The method of claim 1, wherein the second events comprise systolic events, the hemodynamic parameter value measured using a systolic event.

10. The method of claim 1, wherein the second events comprise diastolic hemodynamic events, the hemodynamic parameter value measured using a diastolic hemodynamic event.

11. The method of claim 1, wherein the therapy comprises cardiac resynchronization therapy.

12. The method of claim 1, wherein solving for the first patient-specific equation comprises:

computing a patient-specific value of one of a coefficient and an intercept at a first time point;

repeating measuring the hemodynamic parameter value from the second cardiac signal corresponding to each of the plurality of settings at a second time point later than the first time point;

identifying a second optimal setting from the plurality of settings in response to the measured hemodynamic parameter values at the second time point; and

computing a patient-specific value of the other of the coefficient and the intercept using the second optimal setting.

13. The method of claim 1 wherein the first patient-specific equation comprises

Y=K*X+C

wherein Y is a timing parameter setting, K is a coefficient, X is the measured conduction time interval, and C is an intercept.

14. The method of claim 1, wherein the first pacing control parameter is configured to be updated according to a first frequency.

15. The method of claim 1, wherein the first pacing control parameter is configured to be updated according to a rate of cardiac conduction time interval measurement.

16. The method of claim 1 wherein the patient-specific equation is configured to be updated according to a second frequency of performing heart sound signal analysis.

17. A medical device for controlling and delivering a cardiac pacing therapy, the device comprising:

a plurality of electrodes for sensing a first cardiac signal comprising first events corresponding to cardiac electrical events;

a physiological sensor for sensing a second cardiac signal comprising second events corresponding to cardiac hemodynamic events;

a signal generator for delivering a pacing therapy to a patient'"'"'s heart via the plurality of electrodes; and

a processor to;

measure a cardiac conduction time interval using the first cardiac signal,

control the signal generator to deliver a pacing therapy and adjust a first pacing control parameter to a plurality of settings during the pacing therapy delivery,

measure a hemodynamic parameter value from the second cardiac signal corresponding to each of the plurality of settings,

identify an optimal setting from the plurality of settings in response to the measured hemodynamic parameter values,

uses the identified optimal setting and the measured cardiac conduction time interval to solve for a first patient-specific equation configured to be used to adjust the first pacing control parameter based on cardiac conduction time interval, the first patient-specific equation defining the first pacing control parameter as a function of the cardiac conduction time interval, and

use the first patient-specific equation to compute a setting for the first pacing control parameter based on the cardiac conduction time interval.

18. The device of claim 17, wherein solving for the first patient-specific equation comprises computing a patient-specific value of at least one of a coefficient and an intercept.

19. The device of claim 17, wherein the processor is further configured to:

repeat measuring the cardiac conduction time interval to obtain an updated cardiac conduction time interval; and

use the first patient-specific equation to compute an updated setting for the first pacing control parameter based on the updated cardiac conduction time interval.

20. The device of claim 17, wherein the processor is further configured to:

set a first time interval for updating the first patient-specific equation;

upon expiration of the first time interval, repeat measuring the hemodynamic parameter value from the second cardiac signal corresponding to each of the plurality of settings and identifying an updated optimal setting from the plurality of settings in response to the measured hemodynamic parameter values; and

use the updated optimal setting to solve for an updated first patient-specific equation.

21. The device of claim 20, wherein the processor is further configured to:

set a second time interval for updating the cardiac conduction time interval measurement, the second time interval different than the first time interval; and

upon expiration of the second time interval, repeat measurement of the cardiac conduction time interval to obtain an updated cardiac conduction time interval and use the updated first patient-specific equation to compute an updated setting for the first pacing control parameter based on the updated conduction time interval.

22. The device of claim 17, wherein the processor is further configured to:

use an identified optimal setting of a second pacing control parameter and the measured cardiac conduction time interval to solve for a second patient-specific equation configured to be used to adjust the second pacing control parameter based on cardiac conduction time interval, the second patient-specific equation defining the second pacing control parameter as a function of the cardiac conduction time interval;

control the signal generator to selectively deliver the pacing therapy in one of a first pacing mode and a second pacing mode in response to the first cardiac signal;

use the first patient-specific equation to compute an optimal setting the first pacing control parameter in response to selectively delivering pacing according to the first pacing mode; and

use the second patient-specific equation to compute an optimal setting for the second pacing control parameter in response to selectively delivering pacing according to the second pacing mode.

23. The device of claim 22, wherein the first and second pacing modes comprise a single ventricle pacing mode and a biventricular pacing mode, respectively, the first pacing control parameter comprising an atrial-ventricular delay and the second pacing control parameter comprising a ventricular-ventricular delay.

24. The device of claim 17, wherein the hemodynamic signal comprises a heart sound signal.

25. The device of claim 17, wherein the second events comprise systolic events, the hemodynamic parameter value measured using a systolic event.

26. The device of claim 17, wherein the second events comprise diastolic events, the hemodynamic parameter value measured using a diastolic event.

27. The device of claim 17, wherein the pacing therapy comprises cardiac resynchronization therapy.

28. The device of claim 17, wherein solving for the first patient-specific equation comprises:

computing a patient-specific value of one of a coefficient and an intercept at a first time point;

repeating measuring the hemodynamic parameter value from the second cardiac signal corresponding to each of the plurality of settings at a second time point later than the first time point;

identifying a second optimal setting from the plurality of settings in response to the measured hemodynamic parameter values at the second time point; and

computing a patient-specific value of the other of the coefficient and the intercept using the second optimal setting.

29. A non-transitory computer-readable medium storing instructions which cause a medical device to perform a method for controlling a cardiac pacing therapy, the method comprising:

sensing a first cardiac signal comprising first events corresponding to cardiac electrical events;

sensing a second cardiac signal comprising second events corresponding to cardiac hemodynamic events;

measuring a cardiac conduction time interval using the first cardiac signal;

controlling a signal generator to deliver a pacing therapy and adjust a first pacing control parameter to a plurality of settings during the pacing therapy delivery;

measuring a hemodynamic parameter value from the second cardiac signal corresponding to each of the plurality of settings;

identifying an optimal setting from the plurality of settings in response to the measured hemodynamic parameter values;

using the identified optimal setting and the measured cardiac conduction time interval to solve for a first patient-specific equation configured to be used to adjust the first pacing control parameter based on cardiac conduction time interval, the first patient-specific equation defining the first pacing control parameter as a function of the cardiac conduction time interval; and

using the first patient-specific equation to compute a setting for the first pacing control parameter based on the cardiac conduction time interval.

30. A method, comprising:

sensing a first cardiac signal comprising first events corresponding to cardiac electrical events;

sensing a second cardiac signal comprising second events corresponding to cardiac hemodynamic events; and

enabling a processor to;

measure a cardiac conduction time interval using the first cardiac signal, cardiac conduction time interval being one of an AV conduction time interval, a P-wave duration, and a QRS duration,

control a signal generator to deliver a pacing therapy and adjust a first pacing control parameter to a plurality of settings during the pacing therapy delivery,

measure a hemodynamic parameter value from the second cardiac signal corresponding to each of the plurality of settings,

identify an optimal setting from the plurality of settings in response to the measured hemodynamic parameter values,

use the identified optimal setting and the measured cardiac conduction time interval to solve for a first patient-specific equation configured to be used to adjust the first pacing control parameter based on cardiac conduction time interval, the first patient-specific equation defining the first pacing control parameter as a function of the cardiac conduction time interval,

use the first patient-specific equation to compute a setting for the first pacing control parameter based on the cardiac conduction time interval,

repeat measuring the cardiac conduction time interval to obtain an updated conduction time interval, and

in response to obtaining the updated cardiac conduction time interval use the first patient-specific equation to compute an updated setting for the first pacing control parameter based on the updated conduction time interval.

31. The method of claim 30, wherein solving for the first patient-specific equation comprises computing a patient-specific value of a coefficient.

32. The method of claim 30, wherein solving for the first patient-specific equation comprises computing a patient-specific value of an intercept.