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System for performing automated solid phase extractions

  • US 9,095,833 B2
  • Filed: 05/31/2013
  • Issued: 08/04/2015
  • Est. Priority Date: 05/31/2012
  • Status: Active Grant
First Claim
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1. A system for automated solid phase extraction comprising:

  • a transfer subsystem including;

    an array of pickup tubes;

    a spring mounted sample holding container platform configured to allow each of said pickup tubes to be controllably inserted to a selected depth of each well on a sample holding container held on said sample holding container platform;

    an array of transfer tubes contiguous with said array of pickup tubes;

    an array of transfer nozzles held in an equally spaced arrangement at terminal ends of said transfer tubes;

    a pressure controlled chamber enclosing and sealing said array of pickup tubes and said spring mounted sample holding container platform, configured to allow pressure driven fluid flow into said pickup tubes, through said transfer tubes and out said transfer nozzles;

    wherein application of pressure from a single source into said chamber is configured to drive fluid through all of said pickup tubes;

    a reaction column array shuttle configured to hold an array of equally spaced reaction columns and move said reaction columns from a first location, where said reaction columns are positioned to receive liquid dispensed from said transfer nozzles, to a second location;

    a dispense subsystem, separate from said transfer subsystem, including;

    a plurality of liquid distribution manifolds in spaced arrangement, each distribution manifold configured to selectably dispense liquid into a plurality of spaced dispense nozzles, wherein when said reaction columns are positioned at said second location, liquid may be dispensed through said reaction columns;

    a plurality of valves, each valve regulating fluid flow through one of said distribution manifolds;

    a collection plate lift configured to allow a multi well collection plate to be positioned such that liquid flowing through each reaction column is collected in a well of said collection plate;

    a waste collection cover positionable between open bottom ends of said spaced reaction columns and said collection plate;

    an automated controller configured to control said transfer subsystem and said dispense subsystem; and

    a waste collection cover shuttle configured to move said waste collection cover from a position where said waste collection cover is between outlets of said reaction columns when said reaction column array is in said second location, and openings of wells of said muiti well collection plate.

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