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Chimeric oligomeric compounds and their use in gene modulation

  • US 9,096,636 B2
  • Filed: 11/04/2003
  • Issued: 08/04/2015
  • Est. Priority Date: 06/06/1996
  • Status: Expired due to Fees
First Claim
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1. A composition comprising a duplex consisting of a first chemically synthesized oligonucleotide and a second chemically synthesized oligonucleotide, wherein:

  • each of the first chemically synthesized oligonucleotide and the second chemically synthesized oligonucleotide independently consists of 17 to 25 linked nucleosides, each nucleoside comprising a nucleobase and a sugar;

    the first chemically synthesized oligonucleotide is 100% complementary to the second chemically synthesized oligonucleotide and to a target mRNA;

    the first chemically synthesized oligonucleotide and the second chemically synthesized oligonucleotide are not covalently linked to each other; and

    the first chemically synthesized oligonucleotide is a gapmer, wherein the gap comprises at least 4 nucleosides, each comprising a 2′

    -hydroxy-pentofuranosyl sugar moiety, and wherein each nucleoside of each wing comprises a 2′

    -sugar modification; and

    the second chemically synthesized oligonucleotide comprises at least one nucleoside that comprises a 2′

    -sugar modification.

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