Analyte sensors and methods of use
First Claim
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1. A biosensor for determining the concentration of a biological analyte in a sample, the biosensor comprising:
- a first substrate, a second substrate, and a spacer layer therebetween forming the biosensor, wherein the biosensor comprises a proximal end and a distal end;
a sample chamber defined between the first substrate and the second substrate bounded by the spacer layer at the proximal end of the biosensor, the sample chamber having a first inlet and a second inlet; and
a first protrusion extending from the first substrate at the first inlet and a second protrusion extending from the first substrate at the second inlet; and
wherein the proximal end has a width and the distal end has a width, and the width of the proximal end is less than the width of the distal end.
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Abstract
Analyte sensors for determining the concentration of an analyte in a sample. The sensors have a sample chamber having an inlet with a projection extending from an edge of the sensor for facilitating flow of sample into the sample chamber.
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Citations
23 Claims
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1. A biosensor for determining the concentration of a biological analyte in a sample, the biosensor comprising:
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a first substrate, a second substrate, and a spacer layer therebetween forming the biosensor, wherein the biosensor comprises a proximal end and a distal end; a sample chamber defined between the first substrate and the second substrate bounded by the spacer layer at the proximal end of the biosensor, the sample chamber having a first inlet and a second inlet; and a first protrusion extending from the first substrate at the first inlet and a second protrusion extending from the first substrate at the second inlet; and wherein the proximal end has a width and the distal end has a width, and the width of the proximal end is less than the width of the distal end. - View Dependent Claims (2, 3, 4)
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5. A biosensor for determining the concentration of a biological analyte in a sample, the biosensor comprising:
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a first substrate and a second substrate forming the biosensor, wherein the biosensor comprises a proximal end and a distal end; a first side edge, a second side edge and an end edge; a sample chamber defined between the first substrate and the second substrate at the proximal end of the biosensor, the sample chamber extending from the first side edge to the second side edge; a first aperture and a second aperture between the first substrate and the second substrate at the first side edge and the second side edge, respectively; and at least one protrusion extending from either the first side edge or the second side edge, proximate the apertures; and wherein the proximal end has a width and the distal end has a width, and the width of the proximal end is less than the width of the distal end. - View Dependent Claims (6, 7, 8, 9, 10, 11)
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12. A biosensor for determining the concentration of a biological analyte in a sample, the biosensor comprising:
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a first substrate and a second substrate; a spacer between the first substrate and the second substrate; a sample chamber having only two inlets, a first inlet and a second inlet, the first inlet and the second inlet defined by the first substrate, second substrate, and spacer; a first projection extending from a first edge of the biosensor at the first inlet, wherein the first projection is defined by the first substrate, and wherein a width of the first projection at the first edge of the biosensor is less than a width of the first inlet; a second projection extending from a second edge of the biosensor at the second inlet, wherein the second projection is defined by the first substrate, and wherein a width of the second projection at the second edge of the biosensor is less than a width of the second inlet; and a distal end having a width and a proximal end having a width, wherein the width of the distal end is less than the width of the proximal end, and the sample chamber is proximate the distal end of the biosensor. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification