On-line measuring system of body substances
First Claim
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1. A measuring system for measuring the concentration of substances or analytes in a body fluid or in a body tissue, comprising:
- a microdialysis probe comprising a multilumen tube and a microdialysis membrane, said tube having at least two longitudinally arranged inner bores, said bores extending from a proximal end of the tube to a distal end of the tube, at least two channels, one from each of said at least two bores to the outside of said tube, wherein said bores are blocked for passage of liquid distally of the respective channels, and a tubular membrane arranged circumferentially around the tube such as to cover the at least two channels, wherein said membrane is sealingly fastened to the tube thereby forming a space between the tube and the membrane, and wherein the probe is beth adapted to be placed in blood or in tissue,a flow through sensor for analysing a fluid having passed said microdialysis probe,a pump for pumping said fluid to and through said microdialysis probe and further to and through said sensor, andtubing connecting said pump to said microdialysis probe and said microdialysis probe to said sensor,said pump effecting a flow rate in said system in the interval 0.2-15 microliters per minute, wherein the sensor comprises a flow channel having a flow resistance or pressure drop adapted to the characteristics of the microdialysis membrane so as to eliminate, or at least substantially reduce, ultra filtering in the microdialysis membrane.
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Abstract
A measuring system (100) for continuously measuring body fluid constituents, said measuring system (100) comprising a microdialysis catheter or probe (110) comprising a microdialysis membrane (116) to be placed in a blood stream or in tissue fluid. The measuring system further comprises a flow through sensor (200) for continuously measuring the concentration of substances present in the fluid that has passed the microdialysis membrane (116). The measuring system (100) further comprises a waste container (126).
12 Citations
57 Claims
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1. A measuring system for measuring the concentration of substances or analytes in a body fluid or in a body tissue, comprising:
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a microdialysis probe comprising a multilumen tube and a microdialysis membrane, said tube having at least two longitudinally arranged inner bores, said bores extending from a proximal end of the tube to a distal end of the tube, at least two channels, one from each of said at least two bores to the outside of said tube, wherein said bores are blocked for passage of liquid distally of the respective channels, and a tubular membrane arranged circumferentially around the tube such as to cover the at least two channels, wherein said membrane is sealingly fastened to the tube thereby forming a space between the tube and the membrane, and wherein the probe is beth adapted to be placed in blood or in tissue, a flow through sensor for analysing a fluid having passed said microdialysis probe, a pump for pumping said fluid to and through said microdialysis probe and further to and through said sensor, and tubing connecting said pump to said microdialysis probe and said microdialysis probe to said sensor, said pump effecting a flow rate in said system in the interval 0.2-15 microliters per minute, wherein the sensor comprises a flow channel having a flow resistance or pressure drop adapted to the characteristics of the microdialysis membrane so as to eliminate, or at least substantially reduce, ultra filtering in the microdialysis membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A measuring system for measuring the concentration of substances or analytes in a body fluid or in a body tissue, comprising:
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a microdialysis probe comprising a microdialysis membrane, wherein the probe is adapted to be placed in blood or in tissue, a flow through sensor for analysing a fluid having passed said microdialysis probe, a pump for pumping said fluid to and through said microdialysis probe and further to and through said sensor, tubing connecting said pump to said microdialysis probe and said microdialysis probe to said sensor, and a waste container connected to an outflow end of said flow channel for collecting fluid flowing out from said flow channel, said waste container comprising an absorbent and a pressure relief valve said pump effecting a flow rate in said system in the interval 0.2-15 microliters per minute, wherein the sensor comprises a flow channel having a flow resistance or pressure drop adapted to the characteristics of the microdialysis membrane so as to eliminate, or at least substantially reduce, ultra filtering in the microdialysis membrane. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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Specification