Method and system for measuring retinal
First Claim
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1. A body-mountable device comprising:
- a shaped polymeric material having a channel formed therein;
a substrate at least partially embedded within the shaped polymeric material;
an antenna disposed on the substrate;
an electrochemical sensor disposed on the substrate and comprising;
a working electrode;
a reagent that selectively reacts with retinal, wherein the reagent is localized within a layer of polymer disposed in the channel proximate to the working electrode, and wherein the polymer comprises 2-hydroxyeth methacrylate units; and
a reference electrode; and
a controller electrically connected to the electrochemical sensor and the antenna, wherein the controller is configured to;
(i) apply a voltage between the working electrode and the reference electrode sufficient to generate an amperometric current through the working electrode related to the concentration of retinal in a fluid to which the body-mountable device is exposed;
(ii) measure the amperometric current; and
(iii) use the antenna to indicate the measured amperometric current.
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Abstract
A body-mountable retinal sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a body surface, such as a cornea. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with retinal. Application of a voltage between the working electrode and the reference electrode causes a current related to a concentration of retinal in a fluid to which the electrochemical sensor is exposed. The current is measured by the body-mountable device and wirelessly communicated.
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Citations
30 Claims
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1. A body-mountable device comprising:
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a shaped polymeric material having a channel formed therein; a substrate at least partially embedded within the shaped polymeric material; an antenna disposed on the substrate; an electrochemical sensor disposed on the substrate and comprising; a working electrode; a reagent that selectively reacts with retinal, wherein the reagent is localized within a layer of polymer disposed in the channel proximate to the working electrode, and wherein the polymer comprises 2-hydroxyeth methacrylate units; and a reference electrode; and a controller electrically connected to the electrochemical sensor and the antenna, wherein the controller is configured to;
(i) apply a voltage between the working electrode and the reference electrode sufficient to generate an amperometric current through the working electrode related to the concentration of retinal in a fluid to which the body-mountable device is exposed;(ii) measure the amperometric current; and
(iii) use the antenna to indicate the measured amperometric current. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method comprising:
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exposing a working electrode and a reference electrode to a fluid via a channel, wherein the working electrode and reference electrode are disposed in a body-mountable device, wherein the working electrode is selectively sensitive to retinal, wherein the working electrode being selectively sensitive to retinal comprises a reagent that selectively interacts with retinal being localized within a layer of polymer disposed in the channel proximate to the working electrode, wherein the polymer comprises 2-hydroxyethyl methacrylate units, wherein the body-mountable device additionally includes an antenna and measurement electronics, and wherein the working electrode, reference electrode, antenna, and measurement electronics are disposed on a substrate that is at least partially embedded in a shaped polymeric material; applying a voltage between the working electrode and the reference electrode sufficient to generate an amperometric current through the working electrode related to the concentration of retinal in the fluid to which the body-mountable device is exposed; measuring the amperometric current through the working electrode; and wirelessly indicating the measured current using the antenna. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A system comprising:
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an antenna configured to wirelessly communicate with a body-mountable device, wherein the body-mountable device is configured to measure a current related to the concentration of retinal in a fluid to which a working electrode and a reference electrode of the body-mountable device are exposed via a channel, wherein the working electrode is selectively sensitive to retinal, wherein the working electrode being selectively sensitive to retinal comprises a reagent that selectively interacts with retinal being localized within a layer of polymer disposed proximate to the working electrode, and wherein the polymer comprises 2-hydroxyethyl methacrylate units; a processor; and a non-transitory computer readable medium containing instructions that, when executed by the processor, cause the system perform functions comprising;
(i) using the radio frequency antenna to interrogate the body-mountable device by transmitting a radio frequency signal, (ii) receiving from the body-mountable device a radio-frequency signal indicating a measured current, (iii) determining a retinal concentration in the fluid based on the indicated measured current. - View Dependent Claims (19, 20, 21)
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22. A method comprising:
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interrogating a body-mountable device, the body-mountable device including an antenna, measurement electronics, and an electrochemical sensor with a working electrode and a reference electrode, wherein a reagent that selectively reacts with retinal is localized within a layer of polymer disposed in a channel proximate to the working electrode, wherein the polymer comprises 2-hydroxyethyl methacrylate units, and wherein the antenna, measurement electronics, and the electrochemical sensor are disposed on a substrate that is at least partially embedded in a shaped polymeric material, by transmitting radio frequency radiation sufficient to power the electrochemical sensor and measurement electronics to create a voltage difference between the working electrode and the reference electrode and to measure a current related to retinal; receiving, from the body-mountable device, a radio frequency signal indicating the measured current; and determining a concentration of retinal based on the measured current indicated by the radio frequency signal. - View Dependent Claims (23, 24, 25)
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26. A method comprising:
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forming a substrate; disposing components on the substrate, wherein the components include an electrochemical sensor having at least a working electrode and a reference electrode, measurement electronics, and a radio frequency antenna; at least partially embedding the substrate and components disposed thereon in a shaped polymeric material, wherein the shaped polymeric material has a channel formed therein; and localizing a reagent that reacts selectively with retinal proximate to the working electrode by forming a layer of polymer in the channel proximate to the working electrode, wherein the reagent that reacts selectively with retinal is localized within the formed layer of polymer, and wherein the polymer comprises 2-hydroxyethyl methacrylate units. - View Dependent Claims (27, 28, 29, 30)
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Specification