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Defined culture conditions of human embryonic stem cells

  • US 9,101,590 B2
  • Filed: 07/28/2006
  • Issued: 08/11/2015
  • Est. Priority Date: 07/29/2005
  • Status: Active Grant
First Claim
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1. A culture medium for the maintenance and proliferation of substantially undifferentiated stem cells, wherein said culture medium comprises a basal medium, a protein comprising a member of the tumor necrosis factor (TNF) family, a protein comprising a member of the Wnt family, a protein comprising insulin, a protein comprising transferrin and a protein comprising fibroblast growth factor (FGF), wherein a population of substantially undifferentiated stem cells cultured in said culture medium proliferates while maintaining a substantially undifferentiated state for at least about 4 passages.

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