Compositions with modulating agents
First Claim
Patent Images
1. A waterless composition comprising one or more active agents and a carrier, said carrier comprisinga) a modulating agent;
- b) a polyol;
c) a surface active agent; and
d) a foam adjuvant;
wherein the one or more active agents are chemically unstable in the carrier in the absence of a modulating agent;
wherein the modulating agent is capable of and is selected to modulate or adjust the artificial pH of the carrier to an artificial pH or to provide an artificial pH buffering effect such that the chemical stability of the at least one active agent is increased as compared to its stability in the carrier without the modulating agentwherein if the waterless composition is packaged in a pressurized container and propellant is added the composition will be capable upon release of expanding to form a breakable foam.
8 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless composition and foam.
953 Citations
46 Claims
-
1. A waterless composition comprising one or more active agents and a carrier, said carrier comprising
a) a modulating agent; -
b) a polyol; c) a surface active agent; and d) a foam adjuvant; wherein the one or more active agents are chemically unstable in the carrier in the absence of a modulating agent; wherein the modulating agent is capable of and is selected to modulate or adjust the artificial pH of the carrier to an artificial pH or to provide an artificial pH buffering effect such that the chemical stability of the at least one active agent is increased as compared to its stability in the carrier without the modulating agent wherein if the waterless composition is packaged in a pressurized container and propellant is added the composition will be capable upon release of expanding to form a breakable foam. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
-
-
41. A waterless composition comprising:
-
at least one active agent and a carrier comprising a) a modulating agent; b) a polyol; c) a surface active agent; d) a foam adjuvant; and e) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the composition wherein the at least one active agent is chemically unstable in the carrier in the absence of a modulating agent; wherein the modulating agent comprises an effective amount of one or more agents that are capable of impeding said destabilization and or are capable of stabilizing the active agent by chelating a metal ion such that the modulating agent is capable of reducing in the waterless carrier the availability of metal ions so the stability of at least one active agent is improved when compared to its stability in the carrier without the modulating agent; and wherein the composition is stored in a pressurized container and upon release expands to form a breakable foam. - View Dependent Claims (42, 43, 44, 45)
-
-
46. A waterless carrier for use with one or more active agents comprising
a) a modulating agent; -
b) a polyol; c) a surface active agent; d) a foam adjuvant; and e) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the composition wherein at least one active agent if present is susceptible to one or more of reaction, breakdown, ionization or oxidation; wherein the modulating agent comprises an effective amount of one or more agents that are capable of impeding said destabilization and or are capable of stabilizing the active agent primarily by modulating or adjusting the artificial pH of the carrier such that the modulating agent is capable of producing in the waterless carrier an artificial pH or an artificial pH buffering effect at about a pH or pH range in which the stability of at least one active agent is improved when compared to its stability in the carrier without the modulating agent and or by chelating a metal ion such that the modulating agent is capable of reducing in the waterless carrier the availability of metal ions so the stability of at least one active agent is improved when compared to its stability in the carrier without the modulating agent; and wherein the composition is stored in an aerosol container and upon release expands to form a breakable foam.
-
Specification