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Immobilised biological entities

  • US 9,101,696 B2
  • Filed: 03/09/2012
  • Issued: 08/11/2015
  • Est. Priority Date: 03/11/2011
  • Status: Active Grant
First Claim
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1. A device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 10,000 to 300,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:

  • 1 and (iv) functional end groups, whereby one or more of said functional end groups have a heparin moiety covalently attached thereto, wherein said heparin moiety is single point covalently attached to the hyperbranched polymer molecule, and wherein the hyperbranched polymer is not a dendrimer.

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