Fluid delivery device

• US 9,101,706 B2
• Filed: 10/12/2010
• Issued: 08/11/2015
• Est. Priority Date: 10/13/2009
• Status: Active Grant

• Current Assignee: Mannkind Corporation
• Original Assignee: Valeritas, Inc. (Zealand Pharma A/S)
• Inventors: Gonnelli, Robert R., Levesque, Steven F.
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): STOHR, LEAH C
• Application Number:
  US13/500,136
• Publication Number:
  US 20130046239A1
• Time in Patent Office: 1,764 Days
• Field of Search: 604131-155
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2005/14506 mechanically driven, e.g. spring or clockwork
• CPC Class Codes: A61M 2202/0007 introduced into the body
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/1454 spring-actuated, e.g. by a clockwork
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/1626 Needle protectors therefor in combination with syringes A61M5/3202; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/16804 Flow controllers
• CPC Class Codes: G01F 11/022 of the gun type and actuated by fluid pressure or by a motor air-operated grease guns F16N5/02; devices to fill holes or cracks B05C17/002

Abstract

A fluid delivery device comprises a housing having a fluid reservoir. A needle is in fluid communication with the fluid reservoir in an engaged position and out of fluid communication with the fluid reservoir in armed and storage positions. A proximal end of a biasing member is coupled to the housing and a distal end of the biasing member is configured to deliver a force to the fluid reservoir. A piston member extends through the biasing member and is coupled to the distal end of the biasing member. The piston member is fixed with respect to the housing in a locked position such that the biasing member does not deliver the force to the fluid reservoir and moveable with respect to the housing in a released position such that the biasing member delivers the force to the fluid reservoir. Transitioning the needle from the storage position to the armed position transitions the piston from the locked position to the released position.

Claims

1. An ambulatory fluid delivery device for delivering a medicament to a patient comprising:

a housing having a fluid reservoir;

a needle having a storage position, an armed position, and an engaged position, the needle being in fluid communication with the fluid reservoir in the engaged position and out of fluid communication with the fluid reservoir in the armed and storage positions;

a biasing member having a proximal end and a distal end, the proximal end of the biasing member being coupled to the housing and the distal end of the biasing member configured to deliver a force to the fluid reservoir;

a hydraulic basal chamber coupled between the biasing member and the fluid reservoir; and

a plunger extending through the biasing member and coupled to the distal end of the biasing member, the plunger being fixed with respect to the housing in a locked position such that the biasing member does not deliver the force to the fluid reservoir and moveable with respect to the housing in a released position such that the biasing member delivers the force to the fluid reservoir,

wherein transitioning the needle from the storage position to the armed position transitions the plunger from the locked position to the released position.

2. The fluid delivery device of claim 1, further comprising a hydraulic pump chamber and a flow restrictor fluidly coupling the hydraulic pump chamber and the hydraulic basal chamber.

3. The fluid delivery device of claim 1, wherein the plunger includes a piston coupled to the hydraulic basal chamber.

4. The fluid delivery device of claim 1, wherein the plunger is releaseably coupled to the housing with a pin extending through the housing and a cap extends over the needle in the storage position, the cap being coupled to the pin such that removing the cap releases the plunger.

5. The fluid delivery device of claim 1, wherein the biasing member comprises at least two overlapping coaxial springs.

6. An ambulatory fluid delivery device for delivering a medicament to a patient comprising:

a housing having a fluid reservoir;

a first biasing member coupled to the housing;

a second biasing member coupled to the first biasing member in series and at least partially overlapping the first biasing member, the first and second biasing members being configured to deliver a force to the fluid reservoir;

a sleeve coupling the first biasing member with the second biasing member, the sleeve having a length generally equal to the length of overlap between the first and second biasing members; and

a plunger extending through the first and second biasing members.

7. The fluid delivery device of claim 6, wherein the plunger is coupled to the second biasing member at a distal end and is releaseably coupled to the housing at a proximal end.

8. The fluid delivery device of claim 7, wherein the plunger is releaseably coupled to the housing with a pin extending through the housing and the plunger.

9. The fluid delivery device of claim 8, further comprising a needle cover coupled to the pin.

10. The fluid delivery device of claim 6, further comprising a hydraulic basal chamber coupled between the first and second biasing members and the hydraulic pump chamber and a flow restrictor fluidly coupling the hydraulic basal chamber and the hydraulic pump chamber.

11. The fluid delivery device of claim 10, wherein the hydraulic pump chamber has a cross sectional area less than the cross sectional area of the hydraulic basal chamber.

12. The fluid delivery device of claim 6, wherein the sleeve has a body, a first flanged end and a second flanged end, the first flanged end extending radially outwardly from the body of the sleeve and configured to couple with an end of the first biasing member, and the second flanged end extending radially inwardly from the body and configured to couple with an end of the second biasing member.

13. An ambulatory fluid delivery device for delivering a medicament to a patient comprising:

an attachment surface configured to engage with a skin surface and having a first thermal conductance;

a hydraulic pump chamber;

a hydraulic basal chamber having an outer wall, a portion of the outer wall being proximate the attachment surface and having a second thermal conductance, the second thermal conductance being greater than the first thermal conductance;

a housing having a bottom surface, wherein the outer wall portion of the hydraulic basal chamber extends outwardly from the bottom surface of the housing;

a flow restrictor fluidly coupling the hydraulic basal chamber and the hydraulic pump chamber;

a fluid reservoir coupled to the hydraulic pump chamber, the fluid reservoir configured to contain a fluid deliverable to a patient; and

an actuator coupled to the hydraulic basal chamber, the actuator configured to pressurize the hydraulic pump chamber to transfer energy through the hydraulic basal chamber and the hydraulic pump chamber to the fluid reservoir to deliver the fluid at a sustained basal rate.

14. The fluid delivery device of claim 13, wherein the attachment surface includes an insulating member.

15. The fluid delivery device of claim 14, wherein the insulating member is at least partially open to at least partially expose the portion of the outer wall of the hydraulic basal chamber proximate the attachment surface.

16. The fluid delivery device of claim 13, wherein the attachment surface is part of the housing, the fluid reservoir is at least partially spaced from the housing.

17. The fluid delivery device of claim 13, wherein the portion of the outer wall of the hydraulic basal chamber has an imaginary tangent generally aligned with the attachment surface.

18. The fluid delivery device of claim 13, wherein the portion of the outer wall of the hydraulic basal chamber is configured to directly contact the skin surface.

19. The fluid delivery device of claim 13, wherein a remainder of the outer wall of the hydraulic basal chamber has a third thermal conductance, the third thermal conductance being less than the second thermal conductance.

20. An ambulatory fluid delivery device for delivering a medicament to a patient comprising:

an attachment surface configured to engage with a skin surface and having a first thermal conductance;

a hydraulic pump chamber;

a hydraulic basal chamber having an outer wall, a portion of the outer wall being proximate the attachment surface and having a second thermal conductance, the second thermal conductance being greater than the first thermal conductance, a remainder of the outer wall of the hydraulic basal chamber having a third thermal conductance, the third thermal conductance being less than the second thermal conductance;

a flow restrictor fluidly coupling the hydraulic basal chamber and the hydraulic pump chamber;

a fluid reservoir coupled to the hydraulic pump chamber, the fluid reservoir configured to contain a fluid deliverable to a patient; and

an actuator coupled to the hydraulic basal chamber, the actuator configured to pressurize the hydraulic pump chamber to transfer energy through the hydraulic basal chamber and the hydraulic pump chamber to the fluid reservoir to deliver the fluid at a sustained basal rate.

21. An ambulatory fluid delivery device for delivering a medicament to a patient comprising:

a housing having an attachment surface configured to engage with a skin surface, the attachment surface having a first thermal conductance;

a hydraulic pump chamber;

a hydraulic basal chamber having an outer wall, a portion of the outer wall being proximate the attachment surface and having a second thermal conductance, the second thermal conductance being greater than the first thermal conductance;

a flow restrictor fluidly coupling the hydraulic basal chamber and the hydraulic pump chamber;

a fluid reservoir coupled to the hydraulic pump chamber, the fluid reservoir configured to contain a fluid deliverable to a patient, the fluid reservoir being at least partially spaced from the housing; and

an actuator coupled to the hydraulic basal chamber, the actuator configured to pressurize the hydraulic pump chamber to transfer energy through the hydraulic basal chamber and the hydraulic pump chamber to the fluid reservoir to deliver the fluid at a sustained basal rate.

22. An ambulatory fluid delivery device for delivering a medicament to a patient comprising:

a housing having a fluid reservoir;

a first biasing member coupled to the housing;

a second biasing member coupled to the first biasing member in series and at least partially overlapping the first biasing member, the first and second biasing members being configured to deliver a force to the fluid reservoir; and

a plunger extending through the first and second biasing members, the plunger being releaseably coupled to the housing with a pin extending through the housing and the plunger.

23. The fluid delivery device of claim 22 further comprising:

a needle cover coupled to the pin.