Method and system for displaying the electric field generated on the brain by transcranial magnetic stimulation

• US 9,101,751 B2
• Filed: 09/11/2007
• Issued: 08/11/2015
• Est. Priority Date: 09/13/2006
• Status: Active Grant

• Current Assignee: Nexstim Oyj
• Original Assignee: Nexstim OY
• Inventors: Hurme, Raine, Autio, Ilkka, Sipil, Perttu, Ruohonen, Jarmo
• Primary Examiner(s): MATTHEWS, CHRISTINE HOPKINS
• Application Number:
  US11/853,232
• Publication Number:
  US 20080161636A1
• Time in Patent Office: 2,891 Days
• Field of Search: 600 9- 15, 600/407, 382/128
• US Class Current: 1/1
• CPC Class Codes: A61N 2/004 specially adapted for a specific therapy
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence
• CPC Class Codes: G06T 17/20 Finite element generation, e.g. wire-frame surface description, tesselation
• CPC Class Codes: G06T 19/00 Manipulating 3D models or images for computer graphics
• CPC Class Codes: G06T 2210/41 Medical

Abstract

A visualization surface representative of a portion of the brain at a depth below the head surface of the subject is generated by combining an actual representation of the head surface with an idealized representation of the head surface. The combining is a function of the depth and is performed to minimize in the visualization surface any irregularities existing in the actual head surface of the subject. A display shows the visualization surface overlaid on a volumetric image of the brain, the electric field induced on a region of the visualization surface by a transcranial magnetic stimulation (“TMS”) induction coil device positioned above the head surface and the TMS coil device. By viewing the display, a user of the TMS coil device can interactively position the TMS coil device in relation to the head surface and, for a target site on the brain at a selected depth, determine the position at which the TMS coil device induces a maximum E-field on a visualization surface corresponding to the selected depth.

Claims

1. An apparatus for generating a representation of a portion of a brain for use in transcranial magnetic stimulation (“

TMS”

) comprising;

a non-transitory computer readable medium having a process encoded thereon including the steps of;

generating an actual representation of a head surface of a head,

generating an idealized representation of the head surface,

weighting the actual and idealized representations with first and second weightings, respectively, wherein the first and second weightings are a function of a depth beneath the head surface,

combining the weighted actual and weighted idealized representations to form an unscaled visualization surface, wherein the visualization surface is representative of a portion of the brain within the head at the depth,

scaling the unscaled visualization surface based on the depth to generate the visualization surface, and

providing for display of the visualization surface, and

a processor configured to perform said process stored on said computer readable medium.

2. The apparatus of claim 1, wherein the non-transitory computer readable medium further comprises process steps encoded thereon including:

computing, based on the visualization surface, an electric field (“

E-field”

) induced by a TMS induction coil device on a portion of the brain at the depth; and

providing for display of the induced E-field on the visualization surface.

3. The apparatus of claim 2, wherein the non-transitory computer readable medium further comprises process steps encoded thereon including:

providing for display of the TMS coil device positioned in relation to the visualization surface, a representation of the head surface corresponding to the actual representation of the head surface and a volumetric representation of the head.

4. The apparatus of claim 3, wherein the non-transitory computer readable medium further comprises process steps encoded thereon including:

generating information representative of the position of the TMS coil device in relation to the head surface for a target site on the visualization surface stimulated by the TMS coil device.

5. The apparatus of claim 4, wherein the non-transitory computer readable medium further comprises process steps encoded thereon including:

providing or automatically storing the position of the TMS coil device after performing the step of;

identifying a single maximum E-field on the visualization surface for the target site.

6. The apparatus of claim 2, wherein the non-transitory computer readable medium further comprises process steps encoded thereon including:

providing for display of a maximum and a minimum of the induced E-field on the visualization surface.

7. The apparatus of claim 1, wherein the non-transitory computer readable medium further comprises process steps encoded thereon including:

wherein the first and second weightings are determined by a linear function of the depth, wherein the sum of the first and second weightings equals one and each of the first and second weightings is not less than zero or more than one.

8. The apparatus of claim 7, wherein the non-transitory computer readable medium further comprises process steps encoded thereon including:

wherein the first weighting decreases as the depth increases and the second weighting decreases as the depth decreases.

9. The apparatus of claim 1, wherein the idealized representation is an ellipsoid.

10. The apparatus of claim 1, wherein the visualization surface is a substantially convex surface.

11. The apparatus of claim 1, wherein the non-transitory computer readable medium further comprises process steps encoded thereon including:

wherein the actual representation is a polyhedral surface mesh defined by a plurality of polygons and generated from a volumetric image of the head, the process further comprising;

generating a smallest convex surface mesh containing the surface mesh defined by a plurality of polygons;

eliminating polygons of the plurality of polygons, from the smallest convex surface mesh, corresponding to a lower portion of the head, polygons of the plurality of polygons having an area exceeding an area of predetermined large polygons and polygons of the plurality of polygons sharing vertices with the polygons having an area exceeding the area of predetermined large polygons, to generate a scalp mesh; and

generating the idealized representation based on the scalp mesh.

12. The apparatus of claim 11, wherein the non-transitory computer readable medium further comprises process steps encoded thereon including:

wherein the generating of the idealized representation based on the scalp mesh further comprises;

computing a centroid of the brain based on vertices of all polygons in the scalp mesh, wherein the idealized representation is formed around the centroid and fitted to the vertices.

13. The apparatus of claim 12, wherein the idealized representation is an ellipsoid.

14. The apparatus of claim 1, wherein the idealized representation is formed from a plurality of idealized representations.

15. The apparatus of claim 1, wherein the idealized representation is formed from a plurality of n idealized representations idealized_n, wherein each of the idealized_n representations has a weighting W_ideal-n which is a function of a position of a projection of a vector V from a point on a surface mesh onto the corresponding idealized_n representation, in relation to a predetermined portion of the brain.

16. The apparatus of claim 1, wherein the actual representation is derived from magnetic resonance imaging data representative of an anatomical configuration of the head.

17. The apparatus of claim 1, wherein the non-transitory computer readable medium further comprises process steps encoded thereon including:

comparing the visualization surface with the actual representation of the head surface;

computing a differential between the visualization surface and the actual representation based on the comparing; and

generating a new visualization surface by combining the actual and idealized representations with an adjustment, if the differential exceeds a predetermined threshold.

18. The apparatus of claim 17, wherein the adjustment is a function of the differential.

19. The apparatus of claim 1, wherein the combining is a function of at least one optimization criteria and a constraint.

20. The apparatus of claim 19, wherein the constraint is a function of an area of interest in the brain and quality of image data representative of the head for the area of interest in the brain.

21. The apparatus of claim 1, wherein the processor generates control information for controlling position and orientation of a TMS coil device in relation to the head, based on an actual position of the TMS coil device in relation to the head surface and a computation of an electric field induced on the visualization surface, to maintain a constant amplitude electric field induced on the visualization surface.