System for mixing and dispersing microbubble pharmaceuticals

• US 9,101,895 B2
• Filed: 04/15/2011
• Issued: 08/11/2015
• Est. Priority Date: 04/15/2011
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Lim, Hae Won, Davis, Cynthia Elizabeth Landberg, Rothman, James Edward
• Primary Examiner(s): Savage, Matthew O
• Application Number:
  US13/087,731
• Publication Number:
  US 20120263009A1
• Time in Patent Office: 1,579 Days
• Field of Search: 366144-146, 366/192, 366/275
• US Class Current: 1/1
• CPC Class Codes: B01F 2101/22 Mixing of ingredients for pharmaceutical or medical compositions
• CPC Class Codes: B01F 31/55 the materials to be mixed being contained in a flexible bag submitted to periodical deformation
• CPC Class Codes: B01F 35/2209 Controlling the mixing process as a whole, i.e. involving a complete monitoring and controlling of the mixing process during the whole mixing cycle
• CPC Class Codes: B01F 35/5312 with vertical baffles mounted on the walls
• CPC Class Codes: B01F 35/92 for heating the outside of the receptacle, e.g. heated jackets or burners

Abstract

The present invention relates to functionally closed systems for mixing and delivering microbubble pharmaceuticals. Described is a device comprising a rigid outer layer and a flexible bladder wherein mixing occurs using external mixing sources. Also included is a system for dispensing the pharmaceuticals to its end use after mixing. Methods for mixing and dispensing microbubble pharmaceuticals are also described.

Claims

1. A device for mixing microbubble pharmaceuticals, the device comprising:

a rigid outer layer comprising a compression plate, wherein the rigid outer layer and the pressure plate together form a space that can be pressurized with air at a pressure that is higher than an ambient atmosphere surrounding the device;

a flexible bladder positioned within the space, said flexible bladder comprising,

an internal cavity,

an inlet port for receiving the microbubble pharmaceuticals into the internal cavity and adapted to form a closed seal, and

an outlet port for transferring the microbubble pharmaceuticals out of the internal cavity and adapted to form a closed seal,

a heating or cooling source in communication with the flexible bladder and capable of controlling the temperature of the internal cavity, and

wherein said space surrounds the flexible bladder and is filled with pressurized air at a pressure that is higher than said ambient pressure; and

,

wherein the compression plate is capable of being moved in a direction towards the flexible bladder to constrict the bladder and in a direction away from the bladder to permit expansion of the bladder thereby causing mixing of fluid contained within the bladder.

2. The device of claim 1 wherein the flexible bladder further comprises one or more fins forming side walls in the interior cavity of the bladder.

3. The device of claim 1 wherein the flexible bladder further comprises tethering point attachments, wherein pulling on said attachment expands the flexible bladder.