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System for mixing and dispersing microbubble pharmaceuticals

  • US 9,101,895 B2
  • Filed: 04/15/2011
  • Issued: 08/11/2015
  • Est. Priority Date: 04/15/2011
  • Status: Active Grant
First Claim
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1. A device for mixing microbubble pharmaceuticals, the device comprising:

  • a rigid outer layer comprising a compression plate, wherein the rigid outer layer and the pressure plate together form a space that can be pressurized with air at a pressure that is higher than an ambient atmosphere surrounding the device;

    a flexible bladder positioned within the space, said flexible bladder comprising,an internal cavity,an inlet port for receiving the microbubble pharmaceuticals into the internal cavity and adapted to form a closed seal, andan outlet port for transferring the microbubble pharmaceuticals out of the internal cavity and adapted to form a closed seal,a heating or cooling source in communication with the flexible bladder and capable of controlling the temperature of the internal cavity, andwherein said space surrounds the flexible bladder and is filled with pressurized air at a pressure that is higher than said ambient pressure; and

    ,wherein the compression plate is capable of being moved in a direction towards the flexible bladder to constrict the bladder and in a direction away from the bladder to permit expansion of the bladder thereby causing mixing of fluid contained within the bladder.

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