Method and device for controlled laminar flow patterning within a channel
First Claim
1. A device for controlled laminar flow patterning of at least one sample fluid, comprising:
- a body defining a channel network, the channel network including;
a main channel extending along a longitudinal axis and having a first end and a second end defining an output port;
a first input port, the first input port adapted for receiving a first sample fluid of the of at least one sample fluid and for introducing the first sample fluid into the channel network;
a first input channel having an output end interconnected to and communicating with the first end of the main channel and an input end interconnected to and communicating with the first input port, the first input channel having a fluidic resistance;
a fluidic capacitor for receiving a buffer find having a surface tension therein; and
a first buffering channel having a first end directly interconnected to and communicating with the first input port and a second end interconnected to and communicating with the fluidic capacitor, the first buffering channel configured to have a fluidic resistance less than the fluidic resistance of the first input channel such that the first sample fluid received at the first input port initially flows into the first buffering channel;
wherein the surface tension of the buffer fluid in the fluidic capacitor causes the first sample fluid in the first buffering channel to flow through the first input channel and laminarly in the main channel; and
the main channel is free of diffusion ports between the first and second ends of thereof.
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Abstract
A device and method of laminar flow patterning of at least one sample fluid in a main channel in a microfluidic device are provided. A first input channel is provided in the microfluidic device. The first input channel has an output end communicating with the first end of the main channel and an input end communicating with a first input port. A buffer fluid is deposited in the main channel and the first input channel and a first sample fluid is deposited in the first input port. A first pressure is generated in response to the depositing of the first sample fluid in the first input port so as to cause laminar flow of the first sample fluid in the main channel.
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Citations
8 Claims
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1. A device for controlled laminar flow patterning of at least one sample fluid, comprising:
a body defining a channel network, the channel network including; a main channel extending along a longitudinal axis and having a first end and a second end defining an output port; a first input port, the first input port adapted for receiving a first sample fluid of the of at least one sample fluid and for introducing the first sample fluid into the channel network; a first input channel having an output end interconnected to and communicating with the first end of the main channel and an input end interconnected to and communicating with the first input port, the first input channel having a fluidic resistance; a fluidic capacitor for receiving a buffer find having a surface tension therein; and a first buffering channel having a first end directly interconnected to and communicating with the first input port and a second end interconnected to and communicating with the fluidic capacitor, the first buffering channel configured to have a fluidic resistance less than the fluidic resistance of the first input channel such that the first sample fluid received at the first input port initially flows into the first buffering channel; wherein the surface tension of the buffer fluid in the fluidic capacitor causes the first sample fluid in the first buffering channel to flow through the first input channel and laminarly in the main channel; and
the main channel is free of diffusion ports between the first and second ends of thereof.- View Dependent Claims (2, 3, 4, 5)
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6. A device for controlled laminar flow patterning of at least one sample fluid, comprising:
a body defining a channel network, the channel network including; a main channel extending along a longitudinal axis and having a first end and a second end defining an output port; a first input channel having an output end interconnected to and communicating with the first end of the main channel and an input end interconnected to and communicating with a first input port, the first input channel having a fluidic resistance; a fluidic capacitor; a first buffering channel having a first end directly interconnected to and communicating with the first input port and a second end interconnected to and communicating with the fluidic capacitor, the first buffering channel configured to have a fluidic resistance less than the fluidic resistance of the first input channel; a second input channel having an output end interconnected to and communicating with the first end of the main channel and an input end interconnected to and communicating with a second input port, the second input channel having fluidic resistance; and a second buffering channel having a first end directly interconnected to and communicating with the second input port and a second end interconnected to and communicating with the fluidic capacitor, the first buffering channel configured to have a fluidic resistance less than the fluidic resistance of the first input channel. - View Dependent Claims (7, 8)
Specification