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Methods and devices for electronic sensing

  • US 9,103,761 B2
  • Filed: 04/22/2013
  • Issued: 08/11/2015
  • Est. Priority Date: 10/26/2001
  • Status: Expired due to Fees
First Claim
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1. A method of determining entities of a selected entity type in a microfabricated structure, wherein the entity type is selected from macromolecules and ensembles of macromolecules, the method comprising:

  • (a) providing a device comprising a plurality of microfabricated flow channels each having a detection volume with selected physical dimensions and width;

    (b) applying an electric field across the detection volume;

    (c) passing entities of the selected entity type through the detection volume at a selected flow rate;

    (d) measuring changes in current of the applied electric field resulting from each of the entities passing through and past the detection volume; and

    (e) correlating change in current detected in step (d) with characteristics each entity of the selected entity type within the detection volume,wherein the method comprises selecting a microfabricated structure having the physical dimensions and width of the detection volume specified in step (a), in conjunction with a flow rate of the entities through the detection volume specified in step (c), such that the combination of the physical dimensions and width of the flow channel and the flow rate result in only one entity of the selected entity type passing through the detection volume at a time.

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