Automatic isothermal titration microcalorimeter apparatus and method of use
First Claim
1. An automated isothermal titration micro calorimetry (ITC) system arranged to perform a plurality of unattended titration experiments in series, the system comprising:
- a system controller for controlling the automated operation of the ITC a micro calorimeter comprising a sample cell and a reference cell, the sample cell being accessible via a sample cell stem and the reference cell being accessible via a reference cell stem;
an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprising an activator for driving a plunger in the syringe cavity;
a wash station;
a sample fill station;
a pipette translation unit supporting the pipette assembly that places a pipette in position for titration with the titration needle in the sample cell and in position for washing and filling operations with the titration needle in the wash station and the sample fill station;
a cell preparation unit that performs operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.
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Accused Products
Abstract
Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.
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Citations
14 Claims
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1. An automated isothermal titration micro calorimetry (ITC) system arranged to perform a plurality of unattended titration experiments in series, the system comprising:
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a system controller for controlling the automated operation of the ITC a micro calorimeter comprising a sample cell and a reference cell, the sample cell being accessible via a sample cell stem and the reference cell being accessible via a reference cell stem; an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprising an activator for driving a plunger in the syringe cavity; a wash station; a sample fill station; a pipette translation unit supporting the pipette assembly that places a pipette in position for titration with the titration needle in the sample cell and in position for washing and filling operations with the titration needle in the wash station and the sample fill station; a cell preparation unit that performs operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification