Bioresorbable porous film

• US 9,107,979 B2
• Filed: 04/25/2013
• Issued: 08/18/2015
• Est. Priority Date: 12/06/2012
• Status: Active Grant

• Current Assignee: Industrial Technology Research Institute
• Original Assignee: Industrial Technology Research Institute
• Inventors: Lin, Li-Hsin, Chao, Ying-Hsueh, Huang, Hsiu-Hua, Liou, Yu-Bing, Hung, Chih-Bing, Chen, Chin-Fu, Shen, Hsin-Hsin
• Primary Examiner(s): ROGERS, JAMES WILLIAM
• Application Number:
  US13/870,178
• Publication Number:
  US 20140161842A1
• Time in Patent Office: 845 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: C08L 71/02 Polyalkylene oxides

Abstract

A bioresorbable porous film, including a blend mixture of polylactic acid and at least two kinds of polyethylene glycol, wherein the at least two kinds of polyethylene glycol include a first polyethylene glycol, which is in a solid form under ambient temperature and atmospheric pressure, and a second polyethylene glycol, which is in a liquid form under ambient temperature and atmospheric pressure is provided. The film has a porosity of 10%-90%.

Claims

1. A bioresorbable porous film, comprising:

a blend mixture of polylactic acid and at least two kinds of polyethylene glycol;

wherein the at least two kinds of polyethylene glycol comprise a first polyethylene glycol, which is in a solid form under ambient temperature and atmospheric pressure, and a second polyethylene glycol, which is in a liquid form under ambient temperature and atmospheric pressure;

wherein the first polyethylene glycol has a molecular weight in a range of 6000-9000 Da (PEG(6000-9000)), and the second polyethylene glycol has a molecular weight in a range of 300-600 Da (PEG(300-600));

wherein the film is prepared by a blend mixture according to weight ratio of Formula (I),

x/y/z

x+y+z=100%, x=30-70%, y+z=70-30%, 

 

(I)

wherein x, y, and z represent the weight percentages of PLA, PEG(6000-9000), and PEG(300-600), respectively; and

wherein the film has a porosity of 58.40%-90.80%.

2. The bioresorbable porous film as claimed in claim 1, wherein the y is between 50-10, and the z is between 50-10.

3. The bioresorbable porous film as claimed in claim 1, wherein the polylactic acid has a molecular weight in a range of 50,000-400,000 Da.

4. The bioresorbable porous film as claimed in claim 1, further comprising bioactive agents.

5. The bioresorbable porous film as claimed in claim 4, wherein the film has at least about 1wt % of drug content.

6. The bioresorbable porous film as claimed in claim 1, wherein the film has a thickness of about 10 μ

m-200 μ

m.

7. The bioresorbable porous film as claimed in claim 1, wherein the film has a first surface and a second surface opposite to the first surface, and the first surface has a greater porosity than the second surface.

8. The bioresorbable porous film as claimed in claim 1, wherein the film has pores of 0.2 μ

m-3 μ

m in diameter.

9. The bioresorbable porous film as claimed in claim 1, wherein the film is useful for implantation into mammalian tissues or disposal on the mammalian tissues.

10. The bioresorbable porous film as claimed in claim 1, further comprising hydrophilic drugs, hydrophobic drugs or combinations thereof.

11. The bioresorbable porous film as claimed in claim 1, further comprising growth factors.