Cultured tissue transplant device
First Claim
Patent Images
1. A living cell transplant device for treatment of a surgical or accidental corneal wound, wherein the device comprises:
- a. a removable substrate formed in the shape of an ophthalmic conformer having a central zone and a lateral zone peripheral to the central zone, wherein the central zone comprises a concave posterior face and a convex anterior face, and wherein the substrate further comprises an ophthalmologically acceptable material;
b. a releasable layer, coating the concave posterior face;
c. a plurality of living, transplantable cells upon the releasable layer, wherein the releasable layer is designed to facilitate release of the living, transplantable cells upon the corneal wound to effect transplantation thereof; and
d. means for attaching the substrate formed in the shape of an ophthalmic conformer around the wound.
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Abstract
A device for transplanting a graft such as a layer or layers of cultivated, autologous, allogenic or xenogenic cells to cover an accidental or surgical wound. The graft is cultivated and carried on a bed of collagen or other dissolvable or releasable material mounted on a protective substrate molded to conform to the profile of the wounded area and provided with a lateral attachment zone. The device facilitates the graft cultured in vitro to the recipient surface.
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Citations
36 Claims
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1. A living cell transplant device for treatment of a surgical or accidental corneal wound, wherein the device comprises:
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a. a removable substrate formed in the shape of an ophthalmic conformer having a central zone and a lateral zone peripheral to the central zone, wherein the central zone comprises a concave posterior face and a convex anterior face, and wherein the substrate further comprises an ophthalmologically acceptable material; b. a releasable layer, coating the concave posterior face; c. a plurality of living, transplantable cells upon the releasable layer, wherein the releasable layer is designed to facilitate release of the living, transplantable cells upon the corneal wound to effect transplantation thereof; and d. means for attaching the substrate formed in the shape of an ophthalmic conformer around the wound. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A living cell transplant device for treatment of a surgical or accidental corneal wound, wherein the device comprises:
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a. a removable substrate formed in the shape of an ophthalmic conformer having a central zone and a lateral zone peripheral to the central zone, wherein the central zone comprises a concave posterior face and a convex anterior face, and wherein the substrate further comprises an ophthalmologically acceptable material; b. a releasable layer, coating the concave posterior face; c. a plurality of living, transplantable cells embedded within the releasable layer, wherein the releasable layer is designed to facilitate release of the living, transplantable cells upon the corneal wound to effect transplantation thereof; and d. an attacher, wherein said attacher attaches the substrate formed in the shape of an ophthalmic conformer around the wound. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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19. A living cell transplant device for treatment of a surgical or accidental corneal wound, wherein the device comprises:
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a. a removable substrate formed in the shape of a contact lens having a central zone and a lateral zone peripheral to the central zone, wherein the central zone comprises a concave posterior face and a convex anterior face, and wherein the substrate further comprises an ophthalmologically acceptable contact lens material; b. a releasable layer, coating the concave posterior face; c. a plurality of living, transplantable cells upon the releasable layer, wherein the releasable layer is designed to facilitate release of the living, transplantable cells upon the corneal wound to effect transplantation thereof; and d. an attacher for attaching the substrate formed in the shape of a contact lens around the wound. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
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28. A living cell transplant device for treatment of a surgical or accidental corneal wound, wherein the device comprises:
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a. a removable substrate formed in the shape of a contact lens having a central zone and a lateral zone peripheral to the central zone, wherein the central zone comprises a concave posterior face and a convex anterior face, and wherein the substrate further comprises an ophthalmologically acceptable contact lens material; b. a releasable layer, coating the concave posterior face; c. a plurality of living, transplantable cells embedded within the releasable layer, wherein the releasable layer is designed to facilitate release of the living, transplantable cells upon the corneal wound to effect transplantation thereof; and d. an attacher for attaching the substrate formed in the shape of a contact lens around the wound. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36)
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Specification