Method and apparatus for delivering an agent to a kidney
First Claim
Patent Images
1. A method comprising:
- introducing a delivery device to a point within a renal artery, the delivery device comprising a primary cannula, a guidewire cannula and a delivery cannula, the primary cannula having a proximal end and a distal end and a lumen sized to receive the guidewire cannula and the delivery cannula, the delivery cannula being non-expandable and positioned along a length of the guidewire cannula, wherein the guidewire cannula and the delivery cannula have substantially the same width and wherein the guidewire cannula has an open end and the delivery cannula has an occluded distal end and at least one longitudinally disposed opening defined by a wall of the delivery cannula at a position proximal to the distal end of the delivery cannula, and wherein the delivery cannula is positioned with respect to the primary cannula such that the at least one longitudinally disposed opening is distal to the distal end of the primary cannula; and
delivering a treatment agent from the at least one longitudinally disposed opening in a direction perpendicular to a direction of blood flow to create a turbulent blood flow into the kidney in addition to any turbulent conditions from the presence of the delivery device in the renal artery, wherein said treatment agent is capable of inhibiting a biological process contributing to nephropathy.
0 Assignments
0 Petitions
Accused Products
Abstract
A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.
337 Citations
16 Claims
-
1. A method comprising:
-
introducing a delivery device to a point within a renal artery, the delivery device comprising a primary cannula, a guidewire cannula and a delivery cannula, the primary cannula having a proximal end and a distal end and a lumen sized to receive the guidewire cannula and the delivery cannula, the delivery cannula being non-expandable and positioned along a length of the guidewire cannula, wherein the guidewire cannula and the delivery cannula have substantially the same width and wherein the guidewire cannula has an open end and the delivery cannula has an occluded distal end and at least one longitudinally disposed opening defined by a wall of the delivery cannula at a position proximal to the distal end of the delivery cannula, and wherein the delivery cannula is positioned with respect to the primary cannula such that the at least one longitudinally disposed opening is distal to the distal end of the primary cannula; and delivering a treatment agent from the at least one longitudinally disposed opening in a direction perpendicular to a direction of blood flow to create a turbulent blood flow into the kidney in addition to any turbulent conditions from the presence of the delivery device in the renal artery, wherein said treatment agent is capable of inhibiting a biological process contributing to nephropathy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
-
Specification