Device for stimulating neural regeneration and fabrication method thereof

• US 9,108,042 B2
• Filed: 08/16/2012
• Issued: 08/18/2015
• Est. Priority Date: 05/24/2012
• Status: Expired due to Fees

• Current Assignee: National Chiao Tung University (Government of The Republic of China)
• Original Assignee: National Chiao Tung University (Government of The Republic of China)
• Inventors: Chen, Fang-Chung, Chuang, Ming-Kai, Tan, Kim-Shih
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): KIMBALL, JEREMIAH T
• Application Number:
  US13/587,155
• Publication Number:
  US 20130317582A1
• Time in Patent Office: 1,097 Days
• Field of Search: 607/98, 607/114, 607/115, 607/116, 607/118
• US Class Current: 1/1
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: H10K 30/00 Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation integrated devices or assemblies of multiple devices H10K39/00, H10K65/00; electrolytic light-sensitive devices H01G9/20
• CPC Class Codes: H10K 30/50 Photovoltaic [PV] devices

Abstract

The present invention provides a device for stimulating neural regeneration and/or neurite outgrowth and a fabrication method thereof. A photovoltaic component having a substrate, a first conductive layer, an active layer and a second conducting stacked in sequence is formed. The photovoltaic component is encapsulated by an encapsulant with a portion of the first conductive layer and the second conductive layer exposed from the encapsulant. The device is configured to be rolled to form a guiding tube having two open ends and to be placed at a damaged portion of a nerve. When the device is illuminated by light, a photovoltage exists between the first conductive layer and the second conductive layer for producing an electric current, so as to stimulate neural regeneration and repair the damaged portion of a nerve.

Claims

1. A device for stimulating neural regeneration, comprising:

a photovoltaic component having a substrate, a first conductive layer, an active layer and a second conductive layer stacked in sequence; and

an encapsulant for encapsulating the photovoltaic component with a portion of the first conductive layer and a portion of the second conductive layer exposed from the encapsulant, wherein the device is configured to be placed at a damaged portion of a nerve, and when the encapsulated photovoltaic component of the device is illuminated by red or near-infrared light, the encapsulated photovoltaic component has an energy conversion efficiency equal to or greater than 0.0016% at a wavelength of 500 to 1500 nm, and a photovoltage exists between the first conductive layer and the second conductive layer for producing an electric current, so as to stimulate neural regeneration of and repair the damaged portion of the nerves.

2. The device of claim 1, configured to be rolled as a guiding channel having two open ends, so as for the guiding channel to receive the damaged portion of the nerve.

3. The device of claim 1, the device is a scaffold to be disposed at the damaged portion of the nerve.

4. The device of claim 1, wherein the first conductive layer comprises a first electrode sub-layer formed on the substrate and a conductive polymer sub-layer formed on the first electrode sub-layer.

5. The device of claim 4, wherein the first conductive layer is made of indium tin oxide or indium zinc oxide.

6. The device of claim 1, wherein the active layer is made of a mixed semiconductor material of an n-type semiconductor material and a p-type semiconductor material.

7. The device of claim 6, wherein the n-type semiconductor material includes phenyl C61-butyric acid methyl ester, and the p-type semiconductor material includes poly(3-hexylthiophene).

8. The device of claim 1, wherein the second conductive layer comprises a second electrode sub-layer formed on the active layer and an electrical connection sub-layer formed on the second electrode sub-layer.

9. The device of claim 8, wherein the second electrode sub-layer includes calcium, and the electrical connection sub-layer includes aluminum.

10. The device of claim 1, wherein the encapsulant is a biocompatible plastic.

11. A fabrication method of a device for stimulating neural regeneration, comprising the steps of:

forming a photovoltaic component having a substrate, a first conductive layer, an active layer and a second conductive layer stacked in sequence;

encapsulating the photovoltaic component to form the device with a portion of the first conductive layer and a portion of the second conductive layer exposed from an encapsulant, wherein when the encapsulated photovoltaic component is illuminated by red or near-infrared light, the encapsulated photovoltaic component has an energy conversion efficiency equal to or greater than 0.0016% at a wavelength of 500 to 1500 nm; and

rolling the device to form a guiding channel having two open ends, so as for the device to be placed at a damaged portion of a nerve, and such that when the device is illuminated by red or near-infrared light, a photovoltage exists between the first conductive layer and the second conductive layer for producing an electric current, so as to stimulate neural regeneration and repair a damaged portion of a nerve.

12. The fabrication method of claim 11, wherein the first conductive layer is formed by forming a first electrode sub-layer and a conducting polymer sub-layer stacked on the first electrode sub-layer.

13. The fabrication method of claim 11, wherein the second conductive layer is formed by forming a second electrode sub-layer and an electrical connection sub-layer stacked on the second electrode sub-layer.