System and method for planning and monitoring multi-dose radiopharmaceutical usage on radiopharmaceutical injectors

• US 9,108,047 B2
• Filed: 06/03/2011
• Issued: 08/18/2015
• Est. Priority Date: 06/04/2010
• Status: Active Grant

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Bayer Medical Care Inc. (Bayer AG)
• Inventors: Agamaite, James A., Griffith, Scott R., Descalzi, Douglas, Marsh, Charles
• Primary Examiner(s): LACYK, JOHN P
• Application Number:
  US13/700,266
• Publication Number:
  US 20130123567A1
• Time in Patent Office: 1,537 Days
• Field of Search: 600 1- 8
• US Class Current: 1/1
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 3/00 Medical syringes, e.g. enemata; Irrigators A61M5/00 takes precedence; pistons A61M5/315
• CPC Class Codes: A61M 39/28 Clamping means for squeezing flexible tubes, e.g. roller clamps tube strippers A61M1/83
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61N 2005/1021 Radioactive fluid
• CPC Class Codes: A61N 5/00 Radiation therapy ultrasound therapy A61N7/00; devices or apparatus applicable to both therapy and diagnosis A61B6/00
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61N 5/1031 using a specific method of dose optimization
• CPC Class Codes: A61N 5/1038 taking into account previously administered plans applied to the same patient, i.e. adaptive radiotherapy
• CPC Class Codes: A61N 5/1071 for verifying the dose delivered by the treatment plan
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

A method for planning and monitoring radio pharmaceutical usage during a plurality of radio pharmaceutical injection procedures includes: providing a schedule of the plurality of radio pharmaceutical injection procedures to produce a planned patient schedule; based on the planned patient schedule, calculating a multi-dose container configuration for use during the plurality of radio pharmaceutical injection procedures; transferring the planned patient schedule to a radio pharmaceutical fluid delivery system; loading the multi-dose patient configuration into the radio pharmaceutical fluid delivery system; and conducting the plurality of radio pharmaceutical injection procedures based on the planned patient schedule.

Claims

1. A method of planning and monitoring radiopharmaceutical usage, the method comprising:

receiving a patient schedule for a plurality of radiopharmaceutical injection procedures;

based on the patient schedule, determining a multi-dose container configuration for use during the plurality of radiopharmaceutical injection procedures;

transferring the patient schedule to a radiopharmaceutical fluid delivery system;

providing the multi-dose container configuration to the radiopharmaceutical fluid delivery system;

conducting the plurality of radiopharmaceutical injection procedures based on the patient schedule;

monitoring the multi-dose container configuration during the plurality of radiopharmaceutical injection procedures;

determining whether there is a risk that at least one of the plurality of radiopharmaceutical injection procedures may not be completed properly due to one or more patient schedule changes; and

providing an alert in response to the risk being determined.

2. The method of claim 1, wherein the patient schedule comprises, for each of a plurality of patients, a time of a radiopharmaceutical injection procedure for a patient and an activity of radiopharmaceutical to be removed from the multi-dose container configuration for the patient.

3. The method of claim 1, further comprising:

editing the patient schedule after providing the multi-dose container configuration to accommodate one or more patient schedule changes selected from the group consisting of an additional patient, a cancelled patient, a time modification for a patient on the patient schedule, and a modification to an activity of radiopharmaceutical to be removed from the multi-dose container configuration for a patient on the patient schedule.

4. The method of claim 1, wherein monitoring the multi-dose container configuration comprises:

determining a remaining activity and volume of radiopharmaceutical in the multi-dose container configuration to provide a remaining activity estimation; and

adjusting the remaining activity estimation based on isotope decay.

5. The method of claim 1, further comprising:

updating the patient schedule to accommodate a maximum number of the plurality of radiopharmaceutical injection procedures in response to the risk being determined.

6. The method of claim 1, further comprising:

displaying the patient schedule on a graphical user interface of the radiopharmaceutical fluid delivery system.

7. An article comprising a non-transitory machine-readable storage medium comprising instructions that, if executed, enable a processor to:

receive a patient schedule of a plurality of radiopharmaceutical injection procedures;

based on the patient schedule, determine a multi-dose container configuration for use during the plurality of radiopharmaceutical injection procedures;

monitor the multi-dose container configuration during the plurality of radiopharmaceutical injection procedures;

determine whether there is a risk that at least one of the plurality of radiopharmaceutical injection procedures may not be completed properly due to one or more patient schedule changes; and

provide an alert in response to the risk being determined.

8. The article of claim 7, wherein the non-transitory machine-readable storage medium further comprises instructions that, if executed, enable the processor to transfer the patient schedule to a radiopharmaceutical fluid delivery system.

9. The article of claim 7, wherein the patient schedule comprises, for each of a plurality of patients:

a time of an injection procedure for a patient; and

an activity of radiopharmaceutical removed from the multi-dose container configuration for the patient.

10. The article of claim 9, wherein the instructions that, if executed, enable the processor to receive the patient schedule enable the processor to perform at least one step selected from the group consisting of:

receive the time of the injection procedure and the activity of radiopharmaceutical for the patient from a user via a computer;

receive the time of the injection procedure and the activity of radiopharmaceutical for the patient from a memory device associated with the computer; and

receive the time of the injection procedure and the activity of radiopharmaceutical for the patient from a remotely located patient device over a network.

11. The article of claim 7, wherein the non-transitory machine-readable storage medium further comprises instructions that, if executed, enable the processor to edit the patient schedule after providing the multi-dose container configuration to accommodate one or more patient schedule changes selected from the group consisting of an additional patient, a cancelled patient, a time modification for a patient on the patient schedule, and a modification to an activity of radiopharmaceutical to be removed from the multi-dose container configuration for a patient on the patient schedule.

12. A planning and monitoring software stored on a non-transitory storage medium to plan and monitor radiopharmaceutical usage, the software comprising programming instructions that, if executed, enable a processor to:

receive a patient schedule of a plurality of radiopharmaceutical injection procedures;

based on the patient schedule, determine a multi-dose container configuration for use during the plurality of radiopharmaceutical injection procedures;

monitor the multi-dose container configuration during the plurality of radiopharmaceutical injection procedures;

determine whether there is a risk that at least one of the plurality of radiopharmaceutical injection procedures may not be completed properly due to one or more patient schedule changes; and

provide an alert in response to the risk being determined.

13. The planning and monitoring software of claim 12, wherein the software comprises further programming instructions that, if executed, enable the processor to transfer the patient schedule to a radiopharmaceutical fluid delivery system.

14. A radiopharmaceutical fluid delivery device comprising:

a radiopharmaceutical source;

a disposable administration set configured to allow fluid flow from the radiopharmaceutical source to a patient;

a pumping mechanism in operative communication with the disposable administration set and the radiopharmaceutical source, and configured to pump fluid from the radiopharmaceutical source through the disposable administration set to the patient;

a control unit operatively coupled to the pumping mechanism, and configured to receive a patient schedule, determine a multi-dose container configuration for use during a plurality of radiopharmaceutical injection procedures, control the pumping mechanism to conduct the plurality of radiopharmaceutical injection procedures based on the patient schedule, monitor the multi-dose container configuration during the plurality of radiopharmaceutical injection procedures, determine whether there is a risk that at least one of the plurality of radiopharmaceutical injection procedures may not be completed properly due to one or more patient schedule changes, and provide an alert in response to the risk being determined; and

a display unit operatively coupled to the control unit for displaying the patient schedule.

15. The radiopharmaceutical fluid delivery system of claim 14, wherein the disposable administration set comprises:

a medical fluid component;

a radiopharmaceutical component;

a coil component coupled to the medical fluid component and the radiopharmaceutical component; and

a waste container coupled to the medical fluid component, the coil component, and the radiopharmaceutical component.

16. A method of optimizing a schedule of a plurality of radiopharmaceutical injection procedures, the method comprising:

receiving a schedule of the plurality of radiopharmaceutical injection procedures to produce a planned patient schedule;

transferring the planned patient schedule to a radiopharmaceutical fluid delivery system;

changing the planned patient schedule to produce an updated planned patient schedule;

suggesting one or more changes in at least one of a radioactive dose and an infusion time for at least one future patient in the updated planned patient schedule; and

providing an alert if there is a risk that at least one of the plurality of radiopharmaceutical injection procedures may not be completed properly due to the one or more suggested changes.

17. The method of claim 16, further comprising:

determining a new, optimized patient schedule based on the one or more suggested changes.

18. The method of claim 16, wherein changing the planned patient schedule comprises one or more of adding an additional patient, canceling a patient, modifying a procedure time for a patient on the patient schedule, and modifying an activity of radiopharmaceutical to be removed from the multi-dose container configuration for a patient on the patient schedule.